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EC number: 247-465-8 | CAS number: 26115-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
The substance undergoes rapid hydrolysis under neutral conditions, therefore the aquatic toxicity of the hydrolysis products have been considered.
Reliable short-term toxicity tests results are available for freshwater invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata) for
1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione (CAS 26115-70-8). Exposure will have been to the hydrolysis products.
The relevant short-term values are:
Daphnia: EC50 (48 h): >100 mg/L at loading rate of parent substance or >80 mg/L when expressed in terms of concentration of the hydrolysis product, tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione.
Algae: EL50 (72 h): >100 mg/L; NOELR: 100 mg/L and EL10 >100 mg/L at loading rate of parent substance, or >80 mg/L, 80 mg/L and >80 mg/L respectively, when expressed in terms of concentration of the hydrolysis product, tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione.
There are no reliable short-term toxicity to fish data available for 1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione (CAS 26115-70-8).
For the silanol hydrolysis product, 1,3,5-tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione, aquatic effects have been predicted using reliable, freely-available QSAR software (ECOSAR v2.0).
1,3,5-Tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione is predicted to be highly soluble in water but subject to condensation reactions above approximately 100 mg/l, which will limit the effective or functional solubility in water. The effective limit of solubility is therefore expected to be up to approximately 100 mg/L, if prepared with care.
The predicted E(L)C50 values are interpreted in this context.
The relevant estimated short-term values for the hydrolysis product are:
Fish: LC50 (96 h): > effective limit of solubility (ECOSAR v2.0, aromatic triazines algorithm)
Daphnia: EC50 (48 h): > effective limit of solubility (ECOSAR v2.0, aromatic triazines algorithm)
Algae: EC50 (96 h): > effective limit of solubility (ECOSAR v2.0, aromatic triazines algorithm).
The other hydrolysis product, methanol, is not significantly toxic to aquatic organisms in published studies and is not considered further.
Effects on aquatic microorganisms relevant for WWTP are assessed based on an OECD 209 study. A 3 h NOEC value of 180 mg/L for inhibition of total respiration was determined for the substance. The substance hydrolyses rapidly and the results may be expressed in terms of concentration of the hydrolysis product, 1,3,5-tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione, by applying a molecular weight correction: (MW of silanol=489.62/ MW of parent=615.86) * 180 mg/L = 0.795*180 mg/L = 143 mg/L.
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