1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Please refer to attached supporting information

Principles of method if other than guideline:

Recognised published QSAR method (ECOSAR v2.0)

GLP compliance:

no

Test organisms (species):

not specified

Water media type:

freshwater

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione is predicted to be highly soluble in water but subject to condensation reactions above approximately 100 mg/l, which will limit the effective or functional solubility in water.

Remarks:

The predicted EC50 value is much higher than the effective limit of solubility in water. The result is therefore interpreted as 96-h LC50 > effective limit of solubility for the purposes of the registration data set.

Validity criteria fulfilled:

not applicable

Conclusions:

The short-term LC50 in freshwater fish is predicted to be greater than the effective limit of solubility in water based on results derived from a valid (Q)SAR model, but the substance does not completely fall into its applicability domain.

Description of key information

Short-term toxicity to fish: A 96 hour LC50 > effective limit of solubility has been estimated for the silanol hydrolysis product, 1,3,5-tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione (QSAR).

Additional information

There are no reliable aquatic toxicity data available for 1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione (CAS 26115-70-8). The substance undergoes rapid hydrolysis under neutral conditions, so aquatic effects of the silanol hydrolysis product, 1,3,5-tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione, have been predicted using reliable, freely-available QSAR software (ECOSAR v2.0). A 96-hour LC₅₀ value of >1E+06 mg/L has been estimated for the effects of 1,3,5-tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione on mortality of freshwater fish.

1,3,5-Tris[3-(trihydroxysilyl)propyl]-1,3,5-triazinane-2,4,6-trione is predicted to be highly soluble in water but subject to condensation reactions above approximately 100 mg/L, which will limit the effective or functional solubility in water. The predicted E(L)C₅₀ value is interpreted in this context as > effective limit of solubility.

The QSAR prediction for fish is supported by measured data for freshwater invertebrates and algae. The measured data show no effects at the highest concentrations tested. This correlates with the predicted data, that estimate effects at only very high concentrations of the substance, which are therefore greater than the effective solubility of the substance in test media.