Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation, other
Remarks:
Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L regulation based on actual analytical information of the constituents in intermediate substance.
Type of information:
(Q)SAR
Remarks:
Actual analytical information of the constituents in intermediate substance used as input to Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L database.
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The valid Danish QSAR database, Battery model that integrates results from all systems of CASE Ultra, Lead Scope,SciQSAR, is applied for allergic contact dermatitis in guinea pig and human using actual GC-MS (and headspace) data as well as C>4 hydrocarbons from EPI Suite. Due to complex combination of hydrocarbons as UVCB intermediate substance, the input data for Danish QSAR software was actual substance constituents using GC-MS (and headspace) as well as EPI suite available data for C>4 hydrocarbons to provide a comprehensive assessment that cover complete range of known and probable hydrocarbons. In addition, all constituents hazard properties for skin sensitization were analyzed using ECHA C&L database.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2019

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Two methods applied together for assessment:
First, valid Danish QSAR database, Battery model that integrates results from all systems of CASE Ultra, Lead Scope,SciQSAR, is applied for allergic contact dermatitis in guinea pig and human using actual GC-MS (and headspace) data of the intermediate substance. In addition, C>4 hydrocarbons representative information is also added to broaden the analysis from EPI Suite. Due to complex combination of hydrocarbons as UVCB intermediate substance, the input data for Danish QSAR software was actual substance constituents using GC-MS (and headspace) as well as EPI suite available data for C>4 hydrocarbons to provide a comprehensive assessment that cover complete range of known and probable hydrocarbons.
Second, all constituents hazard properties for skin sensitization were checked using ECHA C&L database to find which constituent has skin sensitization potential. In order to be more conservative, some constituents that are not assigned with exact CAS number in the GCMS results but reported as isomers of a known constituent were also analyzed. For those isomers, all possible known structures were considered for hazard properties according to ECHA C&L database. The purpose was to evaluate if total concentration of skin sensitizers may add more than 1% according to CLP regulation for classification.
GLP compliance:
no
Type of study:
other: Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L regulation based on actual analytical information of the constituents in intermediate substance.

Test material

Constituent 1
Reference substance name:
Hydrocarbons from mixed waste plastics, thermo-mechanical depolymerization condensate
Molecular formula:
C5-C29
IUPAC Name:
Hydrocarbons from mixed waste plastics, thermo-mechanical depolymerization condensate
Test material form:
liquid
Details on test material:
Hydrocarbons from mixed waste plastics, thermo-mechanical depolymerization condensate. It is a complex combination of hydrocarbons as described in section one.

In vivo test system

Test animals

Species:
guinea pig

Results and discussion

In vitro / in chemico

Results
Key result
Parameter:
other: Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L regulation based on actual analytical information of the constituents in intermediate substance.
Remarks on result:
other: Danish QSAR battery approach for allergic contact dermatitis is applied as well as analysis of CLP data of all constituents according to C&L regulation based on actual analytical information of the constituents in intermediate substance.
Remarks:
Both assessment approaches from DTU QSAR results and evaluation of all constituents against C&L inventory data revealed No skin sensitization potential.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Both assessment approaches from DTU QSAR results and evaluation of all constituents against C&L inventory data revealed as no skin sensitization potential and therefore, GHS criteria not met.
Executive summary:

Two methods applied together for assessment:

First, valid Danish QSAR database, Battery model that integrates results from all systems of CASE Ultra, Lead Scope,SciQSAR, is applied for allergic contact dermatitis in guinea pig and human using actual GC-MS (and headspace) data of the intermediate substance. In addition, C>4 hydrocarbons representative information is also added to broaden the analysis from EPI Suite. Due to complex combination of hydrocarbons as UVCB intermediate substance, the input data for Danish QSAR software was actual substance constituents using GC-MS (and headspace) as well as EPI suite available data for C>4 hydrocarbons to provide a comprehensive assessment that cover complete range of known and probable hydrocarbons. 

Second, all constituents hazard properties for skin sensitization were checked using ECHA C&L database to find which constituent has skin sensitization potential. In order to be more conservative, some constituents that are not assigned with exact CAS number in the GCMS results but reported as isomers of a known constituent were also analyzed. For those isomers, all possible known structures were considered for hazard properties according to ECHA C&L database. The purpose was to evaluate if total concentration of skin sensitizers may add more than 1% according to CLP regulation for classification. However, evaluation resulted in no skin sensitizer in the constituents.