D-pentose and D-glucose, oligomeric, C12 and C14 alkyl glycosides

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across based on grouping of substances (category approach)

Remarks:

APP category

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Category is coherent for more than 10 endpoints. Ecotoxicological effect is non specific, linked to surfactant properties and no functional groups are present that may be associated with known specific ecotoxicity.

Justification for type of information:

Discussed in the document attached

Cross-reference

Reason / purpose for cross-reference:

read-across source

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: No deviation from OECD-202 guideline, GLP.

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

ca. 12 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

other: Dissolved Organic Carbon

Basis for effect:

mobility

Validity criteria fulfilled:

yes

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

2014

Reference 2

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Version / remarks:

Guidance on information requirements and chemical safety assessment - Chapter R.6: QSARs and
grouping of chemicals - ECHA, May 2008

Principles of method if other than guideline:

Guidance on information requirements and chemical safety assessment - Chapter R.6: QSARs and
grouping of chemicals - ECHA, May 2008

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

D-xylofuranose oligomeric dodecyl glycosides (degree of polymerisation = 1)

Molecular formula:

C15H30O5

IUPAC Name:

D-xylofuranose oligomeric dodecyl glycosides (degree of polymerisation = 1)

Constituent 2

Reference substance name:

D-xylofuranose oligomeric dodecyl glycosides, degree of polymerisation 2

Molecular formula:

C20H38O9

IUPAC Name:

D-xylofuranose oligomeric dodecyl glycosides, degree of polymerisation 2

Constituent 3

Reference substance name:

D-xylofuranose oligomeric tetradecyl glycosides (degree of polymerisation = 1)

Molecular formula:

C17H34O5

IUPAC Name:

D-xylofuranose oligomeric tetradecyl glycosides (degree of polymerisation = 1)

Constituent 4

Reference substance name:

D-xylofuranose oligomeric tetradecyl glycosides, degree of polymerisation 2

Molecular formula:

C20H38O9

IUPAC Name:

D-xylofuranose oligomeric tetradecyl glycosides, degree of polymerisation 2

Constituent 5

Reference substance name:

D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 1

Molecular formula:

C15H30O5

IUPAC Name:

D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 1

Constituent 6

Reference substance name:

D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 2

Molecular formula:

C20H39O9

IUPAC Name:

D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 2

Constituent 7

Reference substance name:

D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 1

Molecular formula:

C15H30O5

IUPAC Name:

D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 1

Constituent 8

Reference substance name:

D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 2

Molecular formula:

C20H38O9

IUPAC Name:

D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 2

Constituent 9

Reference substance name:

Glucose

EC Number:

200-075-1

EC Name:

Glucose

Cas Number:

50-99-7

Molecular formula:

C6H12O6

IUPAC Name:

D-glucose

Constituent 10

Reference substance name:

Xylose

EC Number:

200-400-7

EC Name:

Xylose

Cas Number:

58-86-6

Molecular formula:

C5H10O5

IUPAC Name:

Oxane-2,3,4,5-tetrol (D)

Constituent 11

Reference substance name:

Tetradecanol

EC Number:

204-000-3

EC Name:

Tetradecanol

Cas Number:

112-72-1

Molecular formula:

C14H30O

IUPAC Name:

Tetradecan-1-ol

Constituent 12

Reference substance name:

Dodecan-1-ol

EC Number:

203-982-0

EC Name:

Dodecan-1-ol

Cas Number:

112-53-8

Molecular formula:

C12H26O

IUPAC Name:

Dodecan-1-ol

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

7 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Daphnia 48h-EC50 for APP-6726 is 7.00 mg/l.