Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
The justification of read across is described in the attached justification

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
D-xylofuranose oligomeric dodecyl glycosides (degree of polymerisation = 1)
Molecular formula:
C15H30O5
IUPAC Name:
D-xylofuranose oligomeric dodecyl glycosides (degree of polymerisation = 1)
Constituent 2
Chemical structure
Reference substance name:
D-xylofuranose oligomeric dodecyl glycosides, degree of polymerisation 2
Molecular formula:
C20H38O9
IUPAC Name:
D-xylofuranose oligomeric dodecyl glycosides, degree of polymerisation 2
Constituent 3
Chemical structure
Reference substance name:
D-xylofuranose oligomeric tetradecyl glycosides (degree of polymerisation = 1)
Molecular formula:
C17H34O5
IUPAC Name:
D-xylofuranose oligomeric tetradecyl glycosides (degree of polymerisation = 1)
Constituent 4
Chemical structure
Reference substance name:
D-xylofuranose oligomeric tetradecyl glycosides, degree of polymerisation 2
Molecular formula:
C20H38O9
IUPAC Name:
D-xylofuranose oligomeric tetradecyl glycosides, degree of polymerisation 2
Constituent 5
Chemical structure
Reference substance name:
D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 1
Molecular formula:
C15H30O5
IUPAC Name:
D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 1
Constituent 6
Chemical structure
Reference substance name:
D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 2
Molecular formula:
C20H39O9
IUPAC Name:
D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 2
Constituent 7
Chemical structure
Reference substance name:
D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 1
Molecular formula:
C15H30O5
IUPAC Name:
D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 1
Constituent 8
Chemical structure
Reference substance name:
D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 2
Molecular formula:
C20H38O9
IUPAC Name:
D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 2
Constituent 9
Chemical structure
Reference substance name:
Glucose
EC Number:
200-075-1
EC Name:
Glucose
Cas Number:
50-99-7
Molecular formula:
C6H12O6
IUPAC Name:
D-glucose
Constituent 10
Chemical structure
Reference substance name:
Xylose
EC Number:
200-400-7
EC Name:
Xylose
Cas Number:
58-86-6
Molecular formula:
C5H10O5
IUPAC Name:
Oxane-2,3,4,5-tetrol (D)
Constituent 11
Chemical structure
Reference substance name:
Tetradecanol
EC Number:
204-000-3
EC Name:
Tetradecanol
Cas Number:
112-72-1
Molecular formula:
C14H30O
IUPAC Name:
Tetradecan-1-ol
Constituent 12
Chemical structure
Reference substance name:
Dodecan-1-ol
EC Number:
203-982-0
EC Name:
Dodecan-1-ol
Cas Number:
112-53-8
Molecular formula:
C12H26O
IUPAC Name:
Dodecan-1-ol

Test animals

Species:
mouse

Results and discussion

Main ADME results
Type:
metabolism
Results:
Readily cleaved

Applicant's summary and conclusion

Conclusions:
Based on this read across approach on the APG-C12/C14, the APP 6726 (APP C12-C14) is readily cleaved