Reaction mass of 2-ethylhexyl diphenyl phosphite and bis(2-ethylhexyl) phenyl phosphite and triphenyl phosphite

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well document study, following standard protocols.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OTS 798.1175 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl diphenyl phosphite

EC Number:

239-716-5

EC Name:

2-ethylhexyl diphenyl phosphite

Cas Number:

15647-08-2

Molecular formula:

C20H27O3P

IUPAC Name:

phosphorous acid, 2-ethylhexyl diphenyl ester

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

CD-1

Sex:

male/female

Details on test animals or test system and environmental conditions:

Rats were obtained from Charles River UK.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

Rats were deprived of food for 18 hours prior to treatment and for a further 4 hours after treatment. Doses were administered by gastric intubation. All doses were adjusted to maintain a constant volume of 40 mL/kg.

Doses:

1.31, 2.30, 4.00, 6.90 g/kg

No. of animals per sex per dose:

5 male and 5 female

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

3 840 mg/kg bw

Based on:

test mat.

95% CL:

3 080 - 4 780

Mortality:

Only one mortality was seen at doses up to and including 2300 mg/kg. Mortality was seen in 3 female rat and 2 male rats at 4000 mg/kg. All male and female rats in the 6900 mg/kg doses died.

Clinical signs:

other: Clinical observations were observed at doses starting at 4000 mg/kg and up including hypoactivity, piloerection, and incontience

Applicant's summary and conclusion

Interpretation of results:

sligthly toxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The acute effects in this study were generally seen at doses of 4000 mg/kg and higher, though there was one lone fatality at 1310 mg/kg. Such high doses would generally not be used in modern guideline studies.

Executive summary:

The LD50 was determined to be 3840 mg/kg for males and females. These LD50 are well above the level for classification.