Reaction mass of isopentyl salicylate and 2-methylbutyl salicylate

PBT assessment

PBT assessment: overall result

Reference

Name:

Reaction mass of isopentyl salicylate and 2-methylbutyl salicylate

Type of composition:

legal entity composition of the substance

State / form:

liquid

Reference substance:

Reaction mass of isopentyl salicylate and 2-methylbutyl salicylate

Reference substance:

Reaction mass of isopentyl salicylate and 2-methylbutyl salicylate

PBT status:

the substance is not PBT / vPvB

Justification:

Persistence:

The substance is readily biodegradable. Hence, the substance is not considered to be persistent.

Bioaccumulation:

For the PBT and vPvB assessment a screening criteria has been established, which is log Kow greater than 4.5. Isoamyl salicylate has a measured log Kow of 4.95, which is just above this screening criteria. For organic substances with a log Kow below 4.5 it is assumed that the affinity for the lipids of an organism is insufficient to exceed the B criterion, i.e. a BCF value of 2000 L/kg. Since there is evidence that isoamyl salicylate is metabolised in fish, the aquatic BCF of isoamyl salicylate is expected to be lower than that predicted from log Kow. Indeed, the estimated BCF value for isoamyl Salicyate based on read-across from analogue data is in the range of 380 to 570 L/kg. This is well below the B definitive criterion of BCF > 2000 L/kg. Therefore isoamyl salicylate does not fulfil the B-criteria. The prediction models QSAR indicates the log BCF=2.63 so BCF=426.57 L/kg ww.

 

Toxicity:

E(L)C50 values for fish, daphnia and algae are > 0.1mg/L. Furthermore, there is no evidence of chronic toxicity, STOT RE or CMR effects.