Benzyl 2-methoxy-4-prop-1-enylphenyl ether

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Key result

Water solubility:

0.67 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 10 - <= 11

Conclusions:

The BENZYL ISO EUGENOL solubility in water at 20 ± 0.5 °C based on the mean of the two determinations with the column elution method was 0.670 mg/L.

Executive summary:

A study was performed to assess the water solubility of the test item BENZYL ISO EUGENOL by the column elution method.

This method is based on the elution of the test item with water from a micro-column charged with an inert support material (celite), previously coated with an excess of the test item. The water solubility was given by the mass concentration of the eluate when this has reached a plateau as a function of time. A second experiment was performed at half the flow rate. The test item concentration was regularly measured by HPLC-DAD.

The BENZYL ISO EUGENOL solubility in water at 20 ± 0.5 °C based on the mean of the two determinations with the column elution method was             0.670 mg/L.