Benzyl 2-methoxy-4-prop-1-enylphenyl ether

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 471 (Bacterial Reverse Mutation Assay)

GLP compliance:

yes (incl. QA statement)

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

Benzyl 2-methoxy-4-prop-1-enylphenyl ether

EC Number:

204-370-6

EC Name:

Benzyl 2-methoxy-4-prop-1-enylphenyl ether

Cas Number:

120-11-6

Molecular formula:

C17H18O2

IUPAC Name:

benzyl 2-methoxy-4-prop-1-enylphenyl ether

Method

Species / strain

Species / strain / cell type:

S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2

Metabolic activation:

with and without

Controls

Untreated negative controls:

yes

Negative solvent / vehicle controls:

yes

Positive controls:

yes

Positive control substance:

9,10-dimethylbenzanthracene

9-aminoacridine

2-nitrofluorene

sodium azide

other: 2-aminoanthracene ; cis-Platinum (II) Diammine Dichloride

Results and discussion

Test results

Test results 1

Key result

Species / strain:

S. typhimurium TA 1535

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not specified

Test results 2

Key result

Species / strain:

S. typhimurium TA 1537

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not specified

Test results 3

Key result

Species / strain:

S. typhimurium TA 98

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not specified

Test results 4

Key result

Species / strain:

S. typhimurium TA 100

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not specified

Test results 5

Key result

Species / strain:

E. coli WP2 uvr A pKM 101

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not specified

Applicant's summary and conclusion

Conclusions:

Doses (5000, 1500, 500, 150 and 50 µg/plate) performed from solutions of the test item Benzyl Iso Eugenol BATCH: 017448/1 (LEMI code: LM-18/0151), provided by SOCIETE GRASSOISE DE PARFURMERIE do not induce any mutagenic change in Salmonella typhimurium T1535, TA1537, TA98, TA100 and in E. coli WP2(uvrA-) (pKM101) without, or with metabolic activation, according to the OECD Guidelines n°471.