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EC number: 271-672-2
CAS number: 68603-74-7
The study was conducted todetermine
the oral acute toxicity of Amines, N-tallow alkyltrimethylenedi-,
C4-18-alkyl phosphates, to the rat. The study was designed
to meet the requirements of the following guidelines:
No.423 (2001) "Acute Oral Toxicity, Acute Toxic Class Method"
No 440/2008, part B: "Acute Oral Toxicity, Acute Toxic Class Method"
OPPTS 870.1100 (2002), "Acute Oral Toxicity"
Guidelines (2000), including the most recent revisions.
Initially, the test item was
administered by oral gavage to three female Wistar Han rats at 2000
mg/kg body weight. In a stepwise procedure, two additional groups of
three females were dosed at 300 mg/kg body weight. All animals were
subjected to daily observations and weekly determination of body
weight. Macroscopic examination was performed on the day of death or
after terminal sacrifice (Day 15).
At 2000 mg/kg, one animal was found
dead on Day 8. One animal was killed in extremis on Day 8 and another on
day 10. At 300 mg/kg, no mortality occurred.
At 2000 mg/kg, lethargy, hunched
posture, piloerection, yellow discoloration of the genital region,
chromodacryorrhoea (nose), diarrhoea, lean appearance and/or red
discoloration of the mouth and nose were noted for the animals between
Days 1 and 10. At 300 mg/kg, Lethargy, hunched posture, uncoordinated
movements, shallow respiration, piloerection and/or ptosis were noted
for the animals between Days 1 and 8.
The body weight gain shown by the
surviving animals over the study period was considered to be similar to
that expected for normal untreated animals of the same age and strain.
Abnormalities of the adrenal glands
(enlarged, both sides), thymus (reduced in size) and forestomach
(irregular surface) were found in the animals that were sacrificed for
humane reasons during the study, at macroscopic post mortem
examination. Macroscopic post mortem examination of the surviving
animals at termination did not reveal any abnormalities.
The oral LD50 value of Amines,
N-tallow alkyltrimethylenedi-, C4-18-alkyl phosphates in Wistar Han rats
was established to be within the range of 300-2000 mg/kg body weight.
According to the OECD 423 test guideline, the LD50 cut-off value was
considered to be 500 mg/kg body weight.
According to the Regulation (EC) No
1272/2008 on classification, labelling and packaging of items and
mixtures (including all amendments), Amines, N-tallow
alkyltrimethylenedi-, C4-18-alkyl phosphates should be classified as
Category 4 and should be labeled as H302: Harmful if swallowed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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