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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report date:
1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC Directive 92/69, Annex V - Method B3 and OECD No. 402.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: The test substance was applied undiluted.
Duration of exposure:
24 h
Doses:
2000 mg/kg
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
The general behaviour was not affected by the treatment with
the test substance.


A slight bodyweight loss was seen in 1/5 treated females
between day 1 and day 8. The overall body weight gain of the
other animals was not influenced by treatment.
Gross pathology:
Effects on organs:
No apparent abnormalities were observed at necropsy in all animals.
Other findings:
Signs of toxicity (local):
No cutaneous reactions were observed during the study.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The Dermal LD50 of Pseudo Kharismal is > 2000 mg/kg in rats.
Executive summary:

The Dermal LD50 of Pseudo Kharismal is > 2000 mg/kg in rats.

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