m-bis(2,3-epoxypropoxy)benzene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

The data for this study was accepted for publication on 01 July 1957

Reliability:

other: The acute toxicity of this compound was assessed as part of a larger study on the toxicity of epoxy resins

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Cross-reference

Reason / purpose for cross-reference:

other: Publication

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1958

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Single administration was given to male rats of the Long-Evans strain. The animals were observed for the following 10 days, and those that died were subjected to necropsy. At the end of the observation period, the survivors were killed for necropsy, and sections of their tissues were preserved in 10% formalin for histologic examination. LD50 values were calculated according to the method of Litchfield and Wilcoxon (1948) or the method of Weil (1952). The test item diluted with propylene glycol was given intragastrically to rats.

GLP compliance:

no

Test type:

other: SIngle intragastric adminstration

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

m-bis(2,3-epoxypropoxy)benzene

EC Number:

202-987-5

EC Name:

m-bis(2,3-epoxypropoxy)benzene

Cas Number:

101-90-6

Molecular formula:

C12H14O4

IUPAC Name:

2-({3-[(oxiran-2-yl)methoxy]phenoxy}methyl)oxirane

Test material form:

liquid: viscous

Specific details on test material used for the study:

No data

Test animals

Species:

rat

Strain:

Long-Evans

Sex:

male

Details on test animals or test system and environmental conditions:

Male rats (110-150 g), Long-Evans strain

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

propylene glycol

Details on oral exposure:

The test material was given to male rats (110-150 g) as a single Intragastric administration by means of a ball-point needle and syringe - dose level not reported

VEHICLE
- Concentration in vehicle: 10%
- Amount of vehicle (if gavage): not available
- Justification for choice of vehicle: not available

Doses:

No dose level reported

No. of animals per sex per dose:

five or six males

Control animals:

no

Details on study design:

- Duration of observation period following administration: 10 days
- Necropsy of survivors performed: yes, at the end of the observation period the animals were killed and sections of their tissues were preserved in 10% formalin for histologic examination.
- LD50 values were calculated according to the method of Litchfield and Wilcoxon (1948)
- Other examinations performed: clinical signs

Statistics:

LD50 values with their confidence limits were calculated according to the method of Litchfield and Wilcoxon (1948)

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

2 570 mg/kg bw

Based on:

test mat.

95% CL:

2 200 - 3 000

Mortality:

not reported

Clinical signs:

other: Moderate depression, slight dyspnea. In surviving animals loss of weight and diarrhoea. Animals that died within 48 hours had a blood-tinged nasal discharge.

Gross pathology:

nonspecific, chief effect of local irritation

Other findings:

none

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral toxicity test showed an LD50 of 2570 mg/kg

Executive summary:

Acute oral toxicity: In this study, male rats were administered the resorcinol diglycidyl ether. No administered dose, no number of animals, no mortality or body weight details are reported. The acute oral LD50 for the substance in male rats was determined to be 2570 mg/kg