m-bis(2,3-epoxypropoxy)benzene

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

This study was submitted for publication in 1958

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

The acute toxicity of this compound was assessed as part of a larger study on the toxicity of epoxy resins

Data source

Reference

Reference Type:

publication

Title:

The Toxicology of Epoxy Resins

Author:

Hine CH, Kodama JK, Anderson HH, Simonson DW, Wellington JS.

Year:

1958

Bibliographic source:

AMA Archives of Industrial Health

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Diglycidyl resorcinol was tested for effect on the skin of rabbits. Albino rabbits were clipped over the back and flank and four areas of the back designated for the test, two intact and two scarified with wire mesh. The animals were immobilised an multiple rabbit holder (Lang, 1944), and patches of gauze secured over the areas with adhesive taps. The compounds were introduced under the patches, and the entire trunk of the rabbits enveloped in rubber dam. After 24 hours the rabbits were released, the resins removed, and a first reading made. After 72 hours a second reading was made. Any irritation was scored according to the method of Draize (1955) - the maximum possible score was 8.

GLP compliance:

no

Remarks:

pre-GLP study

Test material

Test material information

Constituent 1

Reference substance name:

m-bis(2,3-epoxypropoxy)benzene

EC Number:

202-987-5

EC Name:

m-bis(2,3-epoxypropoxy)benzene

Cas Number:

101-90-6

Molecular formula:

C12H14O4

IUPAC Name:

2-({3-[(oxiran-2-yl)methoxy]phenoxy}methyl)oxirane

Test material form:

liquid: viscous

Specific details on test material used for the study:

Diglycidyl resorcinol; no other details reported.

Test animals

Species:

rabbit

Strain:

not specified

Remarks:

Albino

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.0 - 3.2 kg

Test system

Type of coverage:

occlusive

Preparation of test site:

other: clipped and abraded

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not reported

Duration of treatment / exposure:

24 hours

Observation period:

72 Hours

Number of animals:

Males; number not specified

Details on study design:

Diglycidyl resorcinol was tested for effect on the skin of rabbits. Albino rabbits were clipped over the back and flank and four areas of the back designated for the test, two intact and two scarified with wire mesh. The animals were immobilised an multiple rabbit holder (Lang, 1944), and patches of gauze secured over the areas with adhesive taps. The compounds were introduced under the patches, and the entire trunk of the rabbits enveloped in rubber dam. After 24 hours the rabbits were released, the resins removed, and a first reading made. After 72 hours a second reading was made. Any irritation was scored according to the method of Draize (1955) - the maximum possible score was 8.

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Remarks:

reading after 24 and 72 hours

Time point:

72 h

Score:

5

Max. score:

8

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Remarks:

Moderately irritating

Applicant's summary and conclusion

Interpretation of results:

other: Moderately irritating with a score of 5

Remarks:

According to Draize, compounds producing combined averages (primary irritation indices) above 6 are considered severe irritants

Conclusions:

In a skin irritation study with rabbits, diglycidyl resorcinol was applied to the back and flanks of albino rabbits. Based on the results of this study, the substance is considered to be irritating to skin

Executive summary:

The substance was tested in a skin irritation test in rabbits. Exposure to the test item was 24 hours. The mean irritation score of 24 and 72 hours was 5 (maximal score 8). The substance is considered to be moderately irritating to skin. This result is used as weight of evidence with other studies to justify the irritating property of diglycidyl resorcinol to skin.