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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
This endpoint study record is part of a Weight of Evidence approach comprising data of the constituents composing the UVCB substance "Amaryllidaceae, Allium Cepa L. (fresh bulb), Rutaceae, Citrus Limon (L.) Burm. F. (fresh pulp), extract, sodium chloride" constituents.

Data source

Reference Type:
review article or handbook
Sax's Dangerous Properties of Industrial Materials. 11th Edition.
Lewis, R.J.
Bibliographic source:
Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3238

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
this is a published data, from a peer reviewed data handbook.
However, no guideline is mentionned in the summary.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
EC Name:
Sodium chloride
Cas Number:
Molecular formula:
NaCl, sodium chloride, Sirsal, reaction mass of sodium and chlorine

Test animals

not specified
not specified

Administration / exposure

Route of administration:
oral: unspecified
unchanged (no vehicle)

Results and discussion

Effect levels
Key result
not specified
Dose descriptor:
Effect level:
ca. 3 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

A weight of evidence approch was used on to assess the acute toxicity of the UVCB substance "Amaryllidaceae, Allium Cepa L. (fresh bulb), Rutaceae, Citrus Limon (L.) Burm. F. (fresh pulp), extract, sodium chloride".

A bibliographic search was performed on the constituents composing this substance:

-Sodium Chloride 231-598-3, 40 -50%; oral EC 50 (rat) = 3000 mg/kg

-Monosaccharides (mainly glucose EC 200-075-1 and fructose EC 200-333-3) 25 -30%

Glucose, oral EC 50 (rat) =25,800 mg/kg

Fructose,oral EC 50 (rat) =4000 mg/kg

-Disaccharides (mainly saccharose EC 200-334-9) 10 -20%

Saccharose,oral EC 50 (rat) =29,700 mg/kg

-Citric acid EC 201-069-1 , approx 1,5%; oral EC 50 (rat) = 11700mg/kg


As a precautionary principle, the LD50 of the substance should be based on the LD50 of NaCl which is the lowest one:
LD50 Rat oral 3000 mg/kg