Registration Dossier
Registration Dossier
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EC number: 701-307-9 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Due to its physico-chemical characteristics (inert substance, insoluble in water, does not cross biological membranes) it can be inferred that cubic boron nitride is not systemically available, which is further supported by oral, dermal and inhalation toxicity studies conducted with cBN (see chapters 7.2.1, 7.2.2 and 7.2.3 of the IUCLID dossier). In standard OECD tests 423 and 402 cBN exhibited no acute oral toxic characteristics, no acute dermal toxic characteristics and did not cause irritation when applied to rats at a concentration of 2,000 mg/kg body weight. In standard OECD test 403 cBN did not show toxicological characteristics and did not cause irritation when rats being exposed to cBN dust (5.20 mg/L). In addition, all toxicological studies (e.g. Study on Cytotoxicity) available for cBN showed no toxic characteristics of cBN indicating lack of uptake and absence of systemical availability. In addition no systemic or acute effects and no cases of irritation have been observed by medical officers on workers at 3 high volume manufacturers of cBN for all routes of exposure in more than 15 years of production, handling and use of cBN (see statements attachment section 7.3). cBN can be regarded as non-toxic and not irritant and no systemic or local DN(M)ELs could be derived for workers exposed to cBN.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Cubic boron nitride is not used in products for the general population. Therefore no DN(M)ELs have been derived for any route of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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