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EC number: 466-080-8 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Nov 2018 - 01 Oct 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- March 04, 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- Identification: Esacure A 198
Physical Description: White powder
Purity/Composition: See Certificate of Analysis
Storage Conditions: At room temperature protected from light desiccated - Water solubility:
- 0.587 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7.7
- Details on results:
- Preliminary Test:
The content of test item dissolved in the water sample was 2.68 mg/L.
Main Study:
The results for the samples taken at a flow rate set to 12 and 24 mL/h are given in Table 5.
The coefficient of variation (CV) (n = 10) was ≤ 30% at both flow rates. It demonstrated that the system was equilibrated at all flow rates.
The maximum difference (MD) on the mean values of the samples at both flow rates was also ≤ 30%. Based on this, the water solubility of the test item is given as the mean value of these measurements.
The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates.
No test item was detected in the samples from the blank column. Small responses at the retention time of the test item were detected in the chromatograms of the pretreated samples from the blank column. It was considered to derive from carry-over in the analytical system since similar responses were found in the analytical blanks. The maximum contribution to the samples was 0.0040%. It was considered that it has no significant effect on the results of the test samples. - Conclusions:
- The water solubility of the test substance was found to be 0.587 mg/L at 20 °C, under the conditions of the test.
- Executive summary:
In this guideline (OECD 105) study, conducted with GLP certification, the water solubility of the test substance was found to be 0.587 mg/L at 20 °C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 21 September 2006 to 17 October 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- EC's Classilication, Packaging & Labelling 01 Dangerous Substances in the European Union Part 2, Testing Methods, Jan97. Directive 92/69/EC (Annex V to Directive 67/548/EC)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Product Name: LFC 2098
Special Hazards: None specified
Appearance: Sample observed to be a white powder (determined by Chilworth Technology Ltd). - Water solubility:
- 0.745 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 30 °C
- Water solubility:
- 0.434 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 30 °C
- Water solubility:
- 0.501 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 30 °C
- Details on results:
- Mean value Water Solubility (mg/L) : 0.537
- Conclusions:
- Mean value Water Solubility (mg/L) : 0.537
- Executive summary:
In this guideline (EU Method A.6) study, conducted with GLP certification, the test substance (EC 466-080-8) was shown to have a water solubility of 0.537 mg/L
Referenceopen allclose all
The preliminary estimate for the water solubility of LFC 2098, suggests that the Column Elution method should be employed. This method was carried out, however, the results were not repeatable and it was decided that the Flask method for higher solubility compounds should be conducted . This method gave repeatable results and corresponds well with both the estimated water solubility of the compound and the one result gained from the Column Elution method.
Description of key information
Study conducted to recognised testing guidelines with GLP certification.
Key value for chemical safety assessment
- Water solubility:
- 0.587 mg/L
- at the temperature of:
- 20 °C
Additional information
The pH of the aqueous samples was 7.7
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