Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Oct. 1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: internal guideline, not GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1980

Materials and methods

Test guideline
Qualifier:
no guideline available
Deviations:
not applicable
Principles of method if other than guideline:
The tests were carrieà out in the usual manner, using 5 or 10
animals per dosage group. The routes of adninistration were oral
(by gavage). The lethal doses were determined by computer method.
The LD 10, LD 50, and LD 90 are stated for observation periods
of 24 hours and of 10 days.
GLP compliance:
not specified
Test type:
other: no information available, several doses tested
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-amino-2-methylpyrimidine-5-carbonitrile
EC Number:
211-814-2
EC Name:
4-amino-2-methylpyrimidine-5-carbonitrile
Cas Number:
698-29-3
Molecular formula:
C6H6N4
IUPAC Name:
4-amino-2-methylpyrimidine-5-carbonitrile

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
not available
No. of animals per sex per dose:
5 or 10
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
790 mg/kg bw
Based on:
test mat.
Remarks:
after 10 days
95% CL:
>= 660 - <= 920
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Based on:
test mat.
Remarks:
after 24 h
95% CL:
>= 840 - <= 1 160

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance has to be classified as harmful (H302)
Executive summary:

-