Registration Dossier
Registration Dossier
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EC number: 296-417-2 | CAS number: 92671-67-5
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: test according to OECD 202 and GLP guideline
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Principles of method if other than guideline:
- -
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,5-dihydro-3-isopropyl-8-methyl-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate
- EC Number:
- 296-417-2
- EC Name:
- 1,5-dihydro-3-isopropyl-8-methyl-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate
- Cas Number:
- 92671-67-5
- Molecular formula:
- C14H19NO4
- IUPAC Name:
- 8-methyl-3-(propan-2-yl)-1H,3H,5H-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data available
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- no data
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- test substance not difficult
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain: Daphnia magna Stamm Berlin
- Source: LAUS GmbH
- Age at study initiation: 0 - 23 hours
- Feeding during test: no feeding
ACCLIMATION
- Acclimation period: 24 h
- Acclimation conditions (same as test or not): same as test
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- -
Test conditions
- Hardness:
- no data
- Test temperature:
- 20 +- 2°C
- pH:
- 7.7 - 8.0
- Dissolved oxygen:
- 8.5 - 9.3 mg/l
- Salinity:
- no data
- Nominal and measured concentrations:
- -
- Details on test conditions:
- TEST SYSTEM
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: potable water
OTHER TEST CONDITIONS
- Photoperiod: 16 / 8 - Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 150 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL 108 - 300 mg/l
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: not recorded
- Results with reference substance (positive control):
- - Results with reference substance valid? Y
- EC50/LC50: 1.81 mg/l
- Other: 24h EC100i: 3.0 mg/l
NOEL 24h : 1.25 mg/l - Reported statistics and error estimates:
- no data
Any other information on results incl. tables
no additional remarks
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- NOEL 24 h 32 mg/l
24h EC50i 150 mg/l
24h EC100i 320 mg/l - Executive summary:
A range-finding test was followed by a final EC50 test performed under static conditions for 24 hours of exposure. In the final EC50 test Daphnia were exposed for a maximum of 24 hours to 8 different concentrations (320, 220, 150, 100, 68, 46, 32, 0 mg/l)
The study included a blank-control. The test was performed in quadruplicate with 5 daphnia
per vessel. The 24h EC50 was determined to 150 mg/l (95% range: 108 - 300 mg/l).
24 h EC50 (reference substance) = 1.81 mg/l
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