Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-601-8 | CAS number: 108-63-4
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily Biodegradable: > 67% in 28 d (WoE, read-across)
Key value for chemical safety assessment
Additional information
Studies testing the ready biodegradability of Bis(1-methylheptyl) adipate (CAS 108-63-4)are not available. The assessment is based on read-across data available for thestructurally and chemically closely related source substances Bis(2-ethylhexyl) adipate (CAS 103-23-1), Dioctyl adipate(CAS 123-79-5) and Bis(6-methylheptyl) adipate (CAS 1330-86-5). The read-across was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, section 1.5 in order to fulfil the data requirements for this substance. This read-across is justified in detail within the analogue justification in IUCLID Section 13.
The source substanceBis(2-ethylhexyl) adipate (CAS 103-23-1) reached a biodegradation rate of 96% after 28 days in a guideline study following OECD 301B. The biodegradability of the source Dioctyl adipate (CAS 123-79-5) was tested in a study according to OECD guideline 301D at test substance concentrations of 2 and 5 mg/L, respectively. Degradation rates were >67% after 30 d for both test concentrations. The source Bis(6-methylheptyl) adipate (CAS 1330-86-5) was degraded by 70.22% after 28 d in a study according to OECD 301F. All tests on the source substances were performed with non-adapted activated sludge as inoculum and the ten-day window criterion was met in all three studies.
Based on the available results from structurally related read-across substances (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance Bis(1-methylheptyl) adipate (CAS 108-63-4) is readily biodegradable.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
