Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-601-8 | CAS number: 108-63-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects within the limits of water solubility on aquatic algae; read-across
Key value for chemical safety assessment
Additional information
Studies investigating toxic effects of the target substance Bis(1-methylheptyl) adipate (CAS 108-63-4) on aquatic algae are not available. Thus, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substances Bis(7-methyloctyl) adipate (CAS 33703-08-1), and Bis(2-ethylhexyl) adipate (CAS 103-23-1) was conducted to fulfil the data requirements. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in detail within the analogue justification in IUCLID Section 13.
One study in which the toxicity of the source substance Bis(7-methyloctyl) adipate (CAS 33703-08-1) to algae was tested is available. The study was performed according to European standard test guideline, Directive 79/831/EWG, appendix V, part C which is similar to OECD 201. The growth rate of algae (Desmodesmus subspicatus) at nominal test substance concentrations of 0.78, 1.56, 3.13, 6.25, 12.5, 25, 50 and 100 mg/L was followed for 72 h. The determined ErC50 (72 h) was > 100 mg/L. The NOEC (72 h) was 12.5 mg/L based on the algal growth rate.
One study on the toxicity of the source substance Bis(2-ethylhexyl) adipate (CAS 103-23-1) to algae is available. The test was conducted according to OECD 201 as a limit test at a nominal test substance concentration of 50 mg/L. The analytical dose verification determined a test substance concentration of 46 mg/L (meas. arith. mean). An Erc50(72 h) > 46 mg/L (meas. arith. mean) was reported. The determined NOErC (72 h) was 14 mg/L (meas. arith. mean).
Based on the available data for the read across substances no toxic effects on aquatic algae are expected within the limits of water solubility of the target substance Bis(1-methylheptyl) adipate (CAS 108-63-4).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
