Reaction mass of: N,N'-[1,3-Phenylenebis(methylene)bis[12-hydroxyoctadecanamide], N,N'-hexane-1,6-diylbis(12-hydroxyoctadecanamide) and N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide)

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20. Feb. 2019 - 04. July 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: Knudsen cell

Key result

Temp.:

20 °C

Vapour pressure:

0 Pa

Temp.:

25 °C

Vapour pressure:

0 Pa

Conclusions:

The study can be considered as valid. The test item Bisamid has a vapour pressure of 1.37E-6 Pa at 20 °C, which was determined by OECD104.

Executive summary:

The vapour pressure of Bisamid was determined according to OECD 104 resp. EU A.4 using the effusion method (weight loss). Vapour pressure was examined at nine different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (p).

Table 3-a: Vapour Pressures (Effusion Method)

Experiment       T       Mean p       Stand. Dev. p       RSD p

No.                   K       Pa               Pa                            %

5                     363.2   8.93E-04    4.78E-05              5.4%

6                     378.2   2.05E-03    5.94E-04              29.0%

7                     393.2   6.94E-03    1.17E-03              16.9%

In this table, E-0X represents multiplication with 10-x. Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of - 0.9912. For the test item Bisamid, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 1.37E-06 Pa

Vapour pressure at 25 °C: 2.40E-06 Pa

Reference 2

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

EC Directive 92/69 A4, static technique

GLP compliance:

yes

Type of method:

static method

Temp.:

37.96 °C

Vapour pressure:

0.153 Pa

Remarks on result:

other: First vapour pressure

Temp.:

30.36 °C

Vapour pressure:

0.106 Pa

Remarks on result:

other: Second vapour pressure

Temp.:

24.11 °C

Vapour pressure:

0.074 Pa

Remarks on result:

other: Estimated vapour pressure value.

Temp.:

20 °C

Vapour pressure:

0.059 Pa

Remarks on result:

other: Calculated.

Conclusions:

The vapour pressure of 1,3-bis[12-hydroxy-octadecamide-N-methylene]-benzene at 20 °C is 0.059 ± 0.005 Pa by calculation.

Executive summary:

The vapour pressure of 1,3-bis[12-hydroxy-octadecamide-N-methylene]-benzene is assessed in a guideline study according to EU Method A.4 using the static method. The calculated vapour pressure

at 20 °C is 0.059 ± 0.005 Pa.

Reference 3

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

92/69/EEC, A4 (Vapour pressure balance, OECD Guideline No. 104)

GLP compliance:

yes

Type of method:

effusion method: vapour pressure balance

Temp.:

25 °C

Vapour pressure:

0 Pa

Conclusions:

The vapour pressure of 12-hydroxyoctadecanoic acid, reaction products with 1,3-benzenedimethanamine and hexamethylenediamine at 25 °C is 3.26 E-7 Pa.

Executive summary:

The vapour pressure of 12-hydroxyoctadecanoic acid, reaction products with 1,3-benzenedimethanamine and hexamethylenediamine is assessed in a guideline study according to EU Method A.4 using the effusion method (vapour pressure balance). The vapour pressure of the substance at 25 °C is 3.26 E-7 Pa.

Description of key information

The substance consists of multiple different constituents with similar chemical structure: N,N'-ethane-1,2-diylbis(12-hydroxyoctadecanamide), N,N'-hexane-1,6-diylbis(12-hydroxyoctadecanamide) and N,N'-[1,3-phenylenebis(methylene)]bis(12-hydroxyoctadecanamide).There are no experimental data on the multi-constituent substance available. The individual constituents and mixtures of similar structured amides are considered suitable read-across substances. Experimental results from guideline studies on read-across substances:

1,3-bis[12-hydroxy-octadecamide-N-methylene]-benzene: 0.059 Pa (20 °C),

12-hydroxyoctadecanoic acid, reaction products with 1,3-benzenedimethanamine and hexamethylenediamine: 3.26E-7 Pa (25 °C),

N,N'-ethane-1,2-diylbis(12-hydroxyoctadecanamide): 1.37E-6 Pa (20 °C).

As expected for molecules with relatively high molecular weights consisting of long alkyl chains the reported vapour pressures of the read-across substances are low. The properties of the multi-constituent substances is expected to be comparable because it consists of the same or structurally similar molecules. The volatility is considered to be very low and therefore the vapour pressure is negligible. The highest value reported for the read-across substances (0.059 Pa at 20 °C) is selected for chemical safety assessment. Further testing is not considered necessary.

Key value for chemical safety assessment

Vapour pressure:

0.059 Pa

at the temperature of:

20 °C