Reaction mass of octan-2-ylbenzene, octan-3-ylbenzene and octan-4-ylbenzene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
According to conditions described in Column 2 of Section 8.5.2 of Annex VIII testing by the inhalation route is appropriate if exposure to humans via inhalation is likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size. As SHR 1396 is only used in hermetically sealed compressors there is no exposure scenario in which substantial human exposure by inhalation to of SHR 1396 will occur. Also SHR 1396 is a liquid substance with a low vapor pressure (9.5 Pa at 25°C) and thus exposure by inhalation of a vapor is unlikely to occur. Since the criteria in Column 2 of Section 8.5.2 are not fulfilled testing by the inhalation route for SHR 1396 is considered not appropriate and thus testing is waived.

See Cross references for relevant supporting data on uses, toxicological data and physical and chemical properties.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Registration/ Notification status for the use:

use registered according to REACH Article 10; total tonnage manufactured/imported >=10tonnes/year per registrant

Use name:

Use at industrial site by the registrant

Name of activity / technique:

Use of the substance

Environmental release category (ERC):

ERC5: Use at industrial site leading to inclusion into/onto article

Name of activity / technique:

Use of the substance

Process category (PROC):

PROC 1: Chemical production or refinery in closed process without likelihood of exposure or processes with equivalent containment conditions

Substance supplied to that use in form of:

as such

Subsequent service life relevant for this use:

yes

Related assessment:

use assessed in an own CSR

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Vapour pressure at 25°C: 9.5 Pa (EC A.4, OECD 104, OPPTS 830.7950: isothermal thermogravimetric effusion)

Vapour pressure:

9.5 Pa

at the temperature of:

25 °C