6-Amino-5-chloro-2-cyclopyrimidine-4-carboxylic acid

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2019-09-23

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

GLP compliance:

yes (incl. QA statement)

Remarks:

Hess. Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany

Type of method:

OECD harmonised ring method

Key result

Surface tension:

72.1 mN/m

Temp.:

20 °C

Conc.:

885 mg/L

Remarks on result:

other: average concentration of two sample solutions (890 and 881 mg/L)

Individual Results of the Determination of the Concentration by HPLC

The concentrations of the test item in the two sample solutions were determined to be:

890 mg/L (Sample Solution 1)

881 mg/L (Sample Solution 2)

 

Individual Results of the Measurement of the Surface Tension

The measurement was carried out at 20 °C ± 0.5 °C.

A correction factor (Harkins & Jordan) is included.

The age of the test solutions at the beginning of the measurement was 1.25 hours for the sample solution 1 and 2.25 hours for the sample solution 2. The age of the test solution is defined as the period from the preparation of the solution to the recording of the surface tension value.

 

The measured data are given in the following table.

	Experiment 1		Experiment 2
	Time [s]	σM [mN/m]	Time [s]	σM [mN/m]
1. measurement	76.0	71.33	75.8	70.78
2. measurement	121.4	71.30	121.4	70.63
3. measurement	165.2	71.26	167.7	70.59
4. measurement	210.3	71.20	213.8	70.54
5. measurement	256.1	71.18	259.3	70.54
6. measurement	301.4	71.18	304.4	70.54
7. measurement	347.0	71.15	349.6	70.53
8. measurement	393.3	71.13	395.6	70.51
9. measurement	437.5	71.14	440.4	70.51
10. measurement	485.7	71.14	485.9	70.51
Mean σM [mN/m]		71.20		70.57

 

Mean (experiments 1 and 2): σ_mean = 70.89 mN/m

Standard deviation: 0.4 mN/m

Relative standard deviation: 0.6 %

The mean value, multiplied by the calibration factor (F=1.0232) results in:

σ = σ_mean * F = 72.1 mN/m

 

Final Result

The solubility of the test item in water is > 1 g/L, (ca. 3 g/L at 20 °C).

According to the OECD and EEC guideline, solutions of 1 g/L were prepared.

The concentrations of the two solutions were determined by HPLC analyses (results: 890 mg/L for Sample Solution 1 and 881 mg/L for Sample Solution 2).

The surface tension of the test item aqueous solution was:

σ = 72.1 mN/m at 20 °C

Conclusions:

The substance is not surface active, based on a surface tension at 20 °C of 72.1 mN/m measured in water (881-890 mg/L) (OECD Guideline 115, OECD harmonised ring method)

Description of key information

72.1 nN/m at 20 °C and 885 mg/L (OECD Guideline 115, OECD harmonised ring method)

The substance is not surface active.

Key value for chemical safety assessment

Surface tension:

72.1

in mN/m at 20°C and concentration in mg/L:

885