Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental start date 18 September 2018, Experimental completion date 21 September 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance

Test material

1
Chemical structure
Reference substance name:
2-bromo-6-(4-methylbenzoyl)pyridine
EC Number:
618-079-0
Cas Number:
87848-95-1
Molecular formula:
C13H10BrNO
IUPAC Name:
2-bromo-6-(4-methylbenzoyl)pyridine

Results and discussion

Vapour pressure
Key result
Temp.:
25 °C
Vapour pressure:
0.002 Pa

Any other information on results incl. tables

A summary of runs 1 -3 is shown below:

Run 1  Run 2  Run 3 
Correlation:  -0.9993 -0.9912 -0.999
Slope:  -6192 -4720 -4706
Intercept:  17.26 13.16 13.08
Log Vpat 25°C:  -3.51 -2.67 -2.71
Vp (Pa) at 25°C:  3.1 × 10-4  2.2 × 10-3  2.0 × 10-3 

Runs 2 and 3 were in good agreement and higher than the initial run. The vapour pressure was therefore calculated as the mean of the latter two runs and was determined to be 2.1 × 10-3 Pa at 25°C.

A visual assessment of the sample following testing confirmed that the test item had not undergone significant change.

Applicant's summary and conclusion

Conclusions:
The vapour pressure of 2-Bromo-6-(4-toluoyl)pyridine was found to be 2.1 × 10⁻³ Pa at 25°C.