Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental start date 14 September 2018, Experimental completion date 09 November 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

1
Chemical structure
Reference substance name:
2-bromo-6-(4-methylbenzoyl)pyridine
EC Number:
618-079-0
Cas Number:
87848-95-1
Molecular formula:
C13H10BrNO
IUPAC Name:
2-bromo-6-(4-methylbenzoyl)pyridine

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
3.6
Temp.:
25 °C
pH:
7

Any other information on results incl. tables

The logarithm of the capacity factor for the test item was then calculated and the log10Pow value was determined by interpolation. The test item, 2-Bromo-6-(4-toluoyl)pyridine, was thus determined to have a logPow value of 3.6 (equivalent to a Pow value of 4200).

Applicant's summary and conclusion

Conclusions:
The test item, 2-Bromo-6-(4-toluoyl)pyridine, was found to have a logPow value of 3.6.