Registration Dossier
Registration Dossier
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EC number: 619-409-6 | CAS number: 99208-50-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Conclusions on reproductive toxicity:
Both general fragments of DOPO-HQ (DOPO and HQ) are predictednegativeby the TIMES ERBA +S9 model. The predictions are 100% in the model domain and correspond to the experimental data available in TB. This ensure the reliability of the predictions.
The target chemical is predicted negative based on RA prediction with the experimental ERBA data for DOPO and HQ.
Effects on developmental toxicity
Description of key information
NO(A)EL is predicted to be 174 mg/kg bw/dbased on the experimental data of a phosphinate structure and HQ available in Toolbox;
Conclusions on developmental toxicity:
The NO(A)EL of DOPO-HQ with respect to developmental toxicity is predicted to be 174 mg/kg bw/d.
Based on the phosphinate properties with respect to AChE inhibition and the available experimental data for HQ and DOPO`s analogues (CAS 84434-11-7), it could be assumed that the target chemical (DOPO-HQ) will have no or very low developmental toxicity.
Justification for classification or non-classification
Based on the theoretical expert considerations and the modeling results, it is concluded that: the target DOPO-HQ willnot cause reproductive toxicity;
Additional information
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