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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation, other
Remarks:
Sample sent to INTOX PVT. LTD. , 375, Urawade, Tal. Mulshi, Dist. Pune, Maharashtra, 412115, India.
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 days
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 491 (Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Curcuma longa, ext.
EC Number:
283-882-1
EC Name:
Curcuma longa, ext.
Cas Number:
84775-52-0
Molecular formula:
C15H22O
IUPAC Name:
(6S)-2-methyl-6-(4-methylphenyl)hept-2-en-4-one and 2-Methyl-6-(4-methylcyclohexa-2,4-dien-1-yl)hept-2-en-4-one and 2-methyl-6-(4-methylidene-1-cyclohex-2-enyl)hept-2-en-4-one
Test material form:
liquid: viscous

Test animals / tissue source

Species:
rat
Strain:
not specified
Details on test animals or tissues and environmental conditions:
Statens Seruminstitut Rabbit Cornea (SIRC) cells are used for STE test method.

Test system

Vehicle:
other: Mineral oil & Normal saline
Controls:
other: Positive control, Vehicle Control & Medium Control are used for STE test
Amount / concentration applied:
Both 5% and 0.05% concentration of samples were tested for Eye irritation.
Number of animals or in vitro replicates:
3 In Vitro replicates

Results and discussion

In vitro

Results
Irritation parameter:
other: Cell viability
Value:
> 70 - <= 70
Vehicle controls validity:
valid
Positive controls validity:
valid
Remarks on result:
other: The test material falls under " No prediction can be made" Category of UN GHS Classification.

Applicant's summary and conclusion

Interpretation of results:
other: No prediction can be made" as per the UN GHS for classification of Chemicals following OECD guidelines No. 491 using SIRC cell line.
Conclusions:
The study "In-vitro Eye Irritation by Short time Exposure (STE) Test Method" confirms that Turmeric Oil is considered as " No prediction can be made" as per the UN GHS for classification of Chemicals following OECD guidelines No. 491 using SIRC cell line.