Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: the case report
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Methaemoglobinaemia after ingestion of amyl nitrite
Author:
R. J. Forsyth, A. Moulden
Year:
1990
Bibliographic source:
Arch Dis Child

Materials and methods

Test guideline
Qualifier:
no guideline followed
Version / remarks:
Whether inhaled or swallowed, nitrites can produce anoxic states.
The administration of nitrites by any route can produce profound
methemoglobinemia. Tissue anoxemia can result from
methemoglobinemia (Darling and Roughton 1942; Lester andGreenburg 1944). Severe methemoglobinemia can result from
deliberate inhalation of room odorizer products (Home et al. 1979;
Shesser et al. 1981; Guss et al. 1985). Ingestion can produce a more
rapid and malignant methemoglobinemia than can inhalation and can
be lethal (Dixon et al. 1981; Shesser et al. 1980; Shesser et al. 1981;
Smith et al. 1980; Wason et al. 1980) In addition, the alkyl nitrites are metabolized to nitrite ions and the corresponding alcohol, which may lead to delayed deaths or hepatotoxicity Intraperitoneal -Amyl- LD50 - Mouse 130 mg/kg Dewey et al. 1973 (111-152)
Intravenous - Amyl – LD50 - Mouse 51 mg/kg Dewey et al. 1973 (38-68) (24-hours LD50)
Principles of method if other than guideline:
not specified
GLP compliance:
not specified
Test type:
other: not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
female
Remarks on result:
other: not specified

Any other information on results incl. tables

Acute Tox 4; H302

Applicant's summary and conclusion