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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

acute toxicity: oral
Type of information:
other: the case report
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference Type:
Methaemoglobinaemia after ingestion of amyl nitrite
R. J. Forsyth, A. Moulden
Bibliographic source:
Arch Dis Child

Materials and methods

Test guideline
no guideline followed
Version / remarks:
Whether inhaled or swallowed, nitrites can produce anoxic states.
The administration of nitrites by any route can produce profound
methemoglobinemia. Tissue anoxemia can result from
methemoglobinemia (Darling and Roughton 1942; Lester andGreenburg 1944). Severe methemoglobinemia can result from
deliberate inhalation of room odorizer products (Home et al. 1979;
Shesser et al. 1981; Guss et al. 1985). Ingestion can produce a more
rapid and malignant methemoglobinemia than can inhalation and can
be lethal (Dixon et al. 1981; Shesser et al. 1980; Shesser et al. 1981;
Smith et al. 1980; Wason et al. 1980) In addition, the alkyl nitrites are metabolized to nitrite ions and the corresponding alcohol, which may lead to delayed deaths or hepatotoxicity Intraperitoneal -Amyl- LD50 - Mouse 130 mg/kg Dewey et al. 1973 (111-152)
Intravenous - Amyl – LD50 - Mouse 51 mg/kg Dewey et al. 1973 (38-68) (24-hours LD50)
Principles of method if other than guideline:
not specified
GLP compliance:
not specified
Test type:
other: not specified

Test material

Constituent 1
Reference substance name:
2-methylbutan-1-ol; 2-methylbutyl nitrite; pentan-1-ol; pentyl nitrite
EC Number:
Molecular formula:
2-methylbutan-1-ol; 2-methylbutyl nitrite; pentan-1-ol; pentyl nitrite
Test material form:

Administration / exposure

Route of administration:
oral: unspecified
not specified

Results and discussion

Effect levels
Remarks on result:
other: not specified

Any other information on results incl. tables

Acute Tox 4; H302

Applicant's summary and conclusion