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Registration Dossier
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EC number: 951-169-0 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: the case report
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Methaemoglobinaemia after ingestion of amyl nitrite
- Author:
- R. J. Forsyth, A. Moulden
- Year:
- 1 990
- Bibliographic source:
- Arch Dis Child
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- Whether inhaled or swallowed, nitrites can produce anoxic states.
The administration of nitrites by any route can produce profound
methemoglobinemia. Tissue anoxemia can result from
methemoglobinemia (Darling and Roughton 1942; Lester andGreenburg 1944). Severe methemoglobinemia can result from
deliberate inhalation of room odorizer products (Home et al. 1979;
Shesser et al. 1981; Guss et al. 1985). Ingestion can produce a more
rapid and malignant methemoglobinemia than can inhalation and can
be lethal (Dixon et al. 1981; Shesser et al. 1980; Shesser et al. 1981;
Smith et al. 1980; Wason et al. 1980) In addition, the alkyl nitrites are metabolized to nitrite ions and the corresponding alcohol, which may lead to delayed deaths or hepatotoxicity Intraperitoneal -Amyl- LD50 - Mouse 130 mg/kg Dewey et al. 1973 (111-152)
Intravenous - Amyl – LD50 - Mouse 51 mg/kg Dewey et al. 1973 (38-68) (24-hours LD50)
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- 2-methylbutan-1-ol; 2-methylbutyl nitrite; pentan-1-ol; pentyl nitrite
- EC Number:
- 951-169-0
- Molecular formula:
- C15H46N2O10
- IUPAC Name:
- 2-methylbutan-1-ol; 2-methylbutyl nitrite; pentan-1-ol; pentyl nitrite
- Test material form:
- liquid
Constituent 1
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Remarks on result:
- other: not specified
Any other information on results incl. tables
Acute Tox 4; H302
Applicant's summary and conclusion
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