Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 Apr - 14 May 2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Calculation method
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
other: OECD 105
Version / remarks:
1995
Qualifier:
according to guideline
Guideline:
other: EU Method A.6
Qualifier:
according to guideline
Guideline:
other: ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7a: Endpoint specific guidance
Version / remarks:
Version 6.0, 2017
GLP compliance:
no
Type of method:
calculation method (fragments)
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
-2.5
Temp.:
20 °C
Remarks on result:
other: pH is not determined

Octanol Solubility:

According to OECD Test Guideline 105 (1995) and Regulation EC No. 440/2008 Method A.6. the octanol solubility at 20 °C of the test item DMPSA-K2 was determined to be:

cS = 278.4 mg/L

RSD = 8.1%

The partition coefficient is calculated with the determined octanol solubility of this study and the water solubility of study CSL-19-0535.04 by using following equation:

Pow = cn–octanol / cwater

Pow = (0.2784 g/L) / (79.5 g/L)

log POW = -2.5

Description of key information

log Pow = -2.5 at 20 °C (Calculation Method Fragments, OECD 105)

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.5
at the temperature of:
20 °C

Additional information