Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 Dec 2018 - 15 Feb 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of (S)-2-[(R)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide and (S)-2-[(S)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide
Cas Number:
943986-70-7
Molecular formula:
C11H20N2O2
IUPAC Name:
Reaction mass of (S)-2-[(R)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide and (S)-2-[(S)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide
Test material form:
solid
Details on test material:
- Appearance: Off-white solid
- Storage condition of test material: At room temperature protected from light
Specific details on test material used for the study:
Decomposition temp: 250°C

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
<= 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
<= 0 Pa

Any other information on results incl. tables

Table: Results of the vapour pressure isothermal TGA analysis (substance)

Temperature
[°C]

Weight loss
[µg/min]

νT
[g/cm2/h]

logνT

logPT

PT
[Pa]

90

0.680416

8.12 x 10-5

-4.09

-0.12

0.76

 

0.608716

7.27 x 10-5

-4.14

-0.18

0.66

100

1.17836

1.41 x 10-4

-3.85

0.18

1.5

 

1.29080

1.54 x 10-4

-3.81

0.23

1.7

110

3.24890

3.88 x 10-4

-3.41

0.74

5.5

 

2.74666

3.28 x 10-4

-3.48

0.65

4.5

120

6.59939

7.88 x 10-4

-3.10

1.13

14

 

5.45251

6.51 x 10-4

-3.19

1.03

11

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance at 20°C and 25°C was determined to be <=8.2E-5 Pa and <=1.8E-4 Pa, resp.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study based on EC A.4, OECD 104 and OPPTS 830.7950. Validation of the method was performed using a set of five reference substances.

The vapour pressure regression curve (log PT as function of 1/T; with T in K) of the substance was constructed from weight losses measured at 90°C, 100°C, 110°C and 120°C.

The vapour pressure of the substance at 20°C and 25°C was calculated from the vapour pressure curve. Since the weight losses of the test item were obtained with a temperature program of above the melting temperature of the test item, the vapour pressure of the test item could be slightly overestimated. The vapour pressure of the substance at 20°C and 25°C was therefore reported as <=8.2E-5 Pa and <=1.8E-4 Pa, resp.