Reaction mass of (S)-2-[(R)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide and (S)-2-[(S)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24 Dec 2018 - 15 Feb 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

1996

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of (S)-2-[(R)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide and (S)-2-[(S)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide

Cas Number:

943986-70-7

Molecular formula:

C11H20N2O2

IUPAC Name:

Reaction mass of (S)-2-[(R)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide and (S)-2-[(S)-2-Oxo-4-propyl-1-pyrrolidinyl]butyramide

Test material form:

solid

Details on test material:

- Appearance: Off-white solid
- Storage condition of test material: At room temperature protected from light

Specific details on test material used for the study:

Decomposition temp: 250°C

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Temp.:

20 °C

Vapour pressure:

<= 0 Pa

Vapour pressure 2

Key result

Temp.:

25 °C

Vapour pressure:

<= 0 Pa

Any other information on results incl. tables

Table: Results of the vapour pressure isothermal TGA analysis (substance)

Temperature [°C]	Weight loss [µg/min]	νT [g/cm^2/h]	logνT	logPT	PT [Pa]
90	0.680416	8.12 x 10^-5	-4.09	-0.12	0.76
	0.608716	7.27 x 10^-5	-4.14	-0.18	0.66
100	1.17836	1.41 x 10^-4	-3.85	0.18	1.5
	1.29080	1.54 x 10^-4	-3.81	0.23	1.7
110	3.24890	3.88 x 10^-4	-3.41	0.74	5.5
	2.74666	3.28 x 10^-4	-3.48	0.65	4.5
120	6.59939	7.88 x 10^-4	-3.10	1.13	14
	5.45251	6.51 x 10^-4	-3.19	1.03	11

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the substance at 20°C and 25°C was determined to be <=8.2E-5 Pa and <=1.8E-4 Pa, resp.

Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study based on EC A.4, OECD 104 and OPPTS 830.7950. Validation of the method was performed using a set of five reference substances.

The vapour pressure regression curve (log PT as function of 1/T; with T in K) of the substance was constructed from weight losses measured at 90°C, 100°C, 110°C and 120°C.

The vapour pressure of the substance at 20°C and 25°C was calculated from the vapour pressure curve. Since the weight losses of the test item were obtained with a temperature program of above the melting temperature of the test item, the vapour pressure of the test item could be slightly overestimated. The vapour pressure of the substance at 20°C and 25°C was therefore reported as <=8.2E-5 Pa and <=1.8E-4 Pa, resp.