Registration Dossier
Registration Dossier
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EC number: 266-235-8 | CAS number: 66204-44-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Data on toxicokinetics and metabolism cannot be obtained for a complex reaction mixture like the substance. Moreover, data on toxicokinetics and metabolism of MBO as single compound and main constituent cannot be obtained, as the substance is in a complex equilibrium with the reacting compounds and hydrolysis products in aqueous solutions.
Data on the hydrolysis product 2-hydroxypropylamine are not available. Data on formaldehyde, which is considered as the toxicologically most important constituent of the mixture (see Tables in the following sections), are given below.
Table 1 Toxicokinetics and metabolism of formaldehyde
Endpoint | Dermal | Inhalation | Oral |
Absorption | Rat 30-40% | Rat 90% | Rat & mouse almost complete* |
Distribution | Reactivity at the site of first entry (covalent binding to proteins and DNA) and rapid oxidation to formic acid (defence mechanism) | ||
Main metabolites | Formic acid: a) further uptake into the carbon-1-metabolic pathway, b) cleavage to CO2and exhalation, c) excretion of sodium formate via urine | ||
Excretion | Exhaled CO2 | ||
*: limited validity
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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