2H-Pyran, 2-[4'-[difluoro(3,4,5-trifluorophenoxy)methyl]-3',5'-difluoro[1,1'-biphenyl]-4-yl]-5-ethyltetrahydro-

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2008-04-22 to 2008-05-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

92/69/EC

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Principles of method if other than guideline:

NA

GLP compliance:

no

Type of method:

other: Differential Scanning Calorimetry (DSC), additionally Capillary Method for verification)

Key result

Decomposition:

yes

Decomp. temp.:

> 300 - < 325 °C

Boiling Point/Boiling Range (DSC):

Three measurements in aluminium crucibles with a hole showed an endothermic effect after melting in the temperature range 320 - 395°C with an onset temperature of 334, 342 or 364°C.

1) Onset: 334°C, Temp.Range: 325 -365°C,

2) Onset: 364°C, Temp.Range: 320 -390°C

3) Onset: 342°C, Temp.Range: 320 -395°C

The colour of the test item changes over the measurement to dark brown. Due to this it is concluded that the test item boiled under decomposition in the temperature range of 334 - 364°C. Due to the fact that the colour of the test item changed to brown over the DSC-measurements, an additional measurement with capillary method was performed to verify results of the DSC measurements:

1) Set point: 280°C, heating rate: 10 K/min, Endpoint: 400°C, Boiling Point: 300 - 325°C, Remarks: 295°C: quickly small bubbles, 300°C: slow big bubbles and quickly small bubbles, 310°C: test item yellow, 325°C: continuous quickly big and small bubbles, 335°C: bubbles slower, 380°C: bubbles faster. After this measurement the colour of the test item is light brown. According to this result it can be stated that the test item boiled under decomposition in the temperature range of 300 - 325°C. This will be given as final result.

Conclusions:

The test item boiled under decomposition in the temperature range of 300 - 325°C.

Executive summary:

A study was conducted according to Regulation (EC) No 440/2008 method A.2  to determine the boiling point of the test item using differential scanning calorimetry and Capillary Tube in a metal block.

Three measurements in aluminium crucibles with a hole showed an endothermic effect after melting in the temperature range 320 - 395°C with an onset temperature of 334, 342 or 364°C.

The colour of the test item changes over the measurement to dark brown. Due to this it is concluded that the test item boiled under decomposition in the temperature range of 334 - 364°C. Due to the fact that the colour of the test item changed to brown over the DSC-measurements, an additional measurement with capillary method was performed to verify results of the DSC measurements:

1) Set point: 280°C, heating rate: 10 K/min, Endpoint: 400°C, Boiling Point: 300 - 325°C, Remarks: 295°C: quickly small bubbles, 300°C: slow big bubbles and quickly small bubbles, 310°C: test item yellow, 325°C: continuous quickly big and small bubbles, 335°C: bubbles slower, 380°C: bubbles faster. After this measurement the colour of the test item is light brown. According to this result it can be stated that the test item boiled under decomposition in the temperature range of 300 - 325°C.

Description of key information

The test item boiled under decomposition in the temperature range of 300 - 325°C (refrence 4.3 -1).

Additional information

A study was conducted according to Regulation (EC) No 440/2008 method A.2  to determine the boiling point of the test item using differential scanning calorimetry and Capillary Tube in a metal block. Three measurements in aluminium crucibles with a hole showed an endothermic effect after melting in the temperature range 320 - 395°C with an onset temperature of 334, 342 or 364°C. The colour of the test item changes over the measurement to dark brown. Due to this it is concluded that the test item boiled under decomposition in the temperature range of 334 - 364°C. Due to the fact that the colour of the test item changed to brown over the DSC-measurements, an additional measurement with capillary method was performed to verify results of the DSC measurements: 1) Set point: 280°C, heating rate: 10 K/min, Endpoint: 400°C, Boiling Point: 300 - 325°C, Remarks: 295°C: quickly small bubbles, 300°C: slow big bubbles and quickly small bubbles, 310°C: test item yellow, 325°C: continuous quickly big and small bubbles, 335°C: bubbles slower, 380°C: bubbles faster. After this measurement the colour of the test item is light brown. According to this result it can be stated that the test item boiled under decomposition in the temperature range of 300 - 325°C.