Registration Dossier

Administrative data

Endpoint:
dermal absorption, other
Remarks:
expert statement
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
calculation and expert statement

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(trans(trans))-4'-vinyl-4-(4-methylphenyl)bicyclohexyl
EC Number:
439-730-3
EC Name:
(trans(trans))-4'-vinyl-4-(4-methylphenyl)bicyclohexyl
Cas Number:
155041-85-3
Molecular formula:
Hill formula: C21H30 CAS formula: C21H30
IUPAC Name:
(1r,1'r,4r,4'r)-4-ethenyl-4'-(4-methylphenyl)-1,1'-bi(cyclohexane)

Results and discussion

Applicant's summary and conclusion

Conclusions:
Taking into accoung a human body weight of 70 kg, it is anticipated that 5.4 ng test item /kg bw that would be systemically available after dermal exposure of an aqueous solution on both hands for 1 hour.