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Administrative data

Description of key information

Three acute toxicity studie for succinimide are available.

In two acute oral studies an LD50 has been determined of 14 g/kg bw for rats and 11 g/kg bw for mice.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Acute oral toxicity study in rats
GLP compliance:
not specified
Test type:
other: not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
14 000 mg/kg bw
Based on:
test mat.
Mortality:
not specified
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified
Interpretation of results:
GHS criteria not met
Conclusions:
In an acute oral toxicity in rats, an LD50 value of 14 g/kg bw was determined.
Executive summary:

In an acute oral toxicity in rats, an LD50 value of 14 g/kg bw was determined.

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Acute oral toxicity study in mice
GLP compliance:
not specified
Test type:
other: not specified
Specific details on test material used for the study:
not specified
Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
11 000 mg/kg bw
Based on:
not specified
Mortality:
not specified
Clinical signs:
other: not specified
Gross pathology:
not specified
Interpretation of results:
GHS criteria not met
Conclusions:
In an acute oral toxicity in mice, an LD50 value of 11 g/kg bw was determined.
Executive summary:

In an acute oral toxicity in rats, an LD50 value of 11 g/kg bw was determined.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
11 000 mg/kg bw
Quality of whole database:
handbook data

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Based on the available data, succinimide does not warrant classification for acute toxicity. The LD50 value for the oral route was above the limit value for classification (2000 mg/kg bw).