Registration Dossier
Registration Dossier
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EC number: 701-310-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
With high probability acutely not harmful to aquatic organisms. The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
This aquatic toxicity assessment was based on the following data:
Short-term toxicity to fish:
The acute toxicity of the structurally related molecule Diethyleneglycol, propoxylated (CAS 9051 -51 -8) to Fish (Danio rerio) was tested according to EU method C.1 'Acute toxicity for Fish'. No toxic effects were observed during and after 96 hours of exposure at a limit test concentration of 100 mg/L (Currenta 2009/0091/09, 2009). The test concentrations were analytically confirmed. This result is considered to be adaptable for the test substance due to the structural similarities of both molecules.
Short-term toxicity to aquatic invertebrates:
Acute toxicity to aquatic invertebrates was tested using a static approach in a GLP test according to OECD guideline 202. After 48 hours of exposure of the aquatic invertebrate Daphnia magna an EC50 > 100 mg/L was found, related to the analytically verified nominal concentration. The NOEC was determined to be 100 mg/L (highest concentration).
Long-term toxicity to aquatic invertebrates:
The chronic toxicity of the structurally related substance D-Glucitol (Sorbitol), propoxylated (CAS 52625-13-5) was investigated in an OECD 211 guideline study. In this study, the NOEC (21d) on the mortality of Daphnia magna was determined to be 10 mg/L (Bayer 1357 A/05 D, 2005) related to the endpoint mortality. As the endpoint is not based on reproduction the NOEC is not considered for PNEC derivation. This result is considered to be adaptable for the test substance due to the structural similarities of both molecules.
Toxicity to aquatic algae:
The toxicity of the structurally related molecule Diethyleneglycol, propoxylated (CAS 9051-51-8) to algae (Desmodesmus subspicatus) was tested according to EU method C.3 'Algal Inhibition test'. No toxic effects were observed during and after 72 hours of exposure at a limit test concentration of 100 mg/L (Currenta, 2009). The test concentrations were analytically confirmed.
This result is considered to be adaptable for the test substance due to the structural similarities of both molecules.
Toxicity to microorganisms:
As key study concerning acute toxicity to microorganisms a test performed by BASF (2011) according to OECD guideline 209 was identified, using domestic activated sludge as inoculum. In the static test an EC10 of 470 mg/L for the respiration inhibition after 180 minutes of exposure was calculated related to the nominal concentration.
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