Registration Dossier
Registration Dossier
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EC number: 446-810-1 | CAS number: 136239-66-2 1-BUTOXY-2,3-DIFLUORBENZOL; BUPHOL
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 JAN 2002 - 01 FEB 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- Guideline 92/69/EWG, 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 4
- Temp.:
- 25 °C
- Remarks on result:
- other: no pH value stated in the study report
- Details on results:
- Calibration data:
Regresssion: log Pow = a + b log k'
Parameters: a = - 0.7714, b = 0.3561, r = 0.987
log Pow of the test substance:
1st injection: tR = 11.26 min
2nd injection: tR = 11.25 min
3rd injection: tR = 11.25 min
mean: tR = 11.253 min
k = 4.489
logk = 0.6522
log Pow = 4.00 - Conclusions:
- The log Pow was found to be 4.0 (Pow = 9.96E+03).
- Executive summary:
- The partition coefficient n-octanol/water of the test substance was determined according to the "HPLC method" described in guideline 92/69/EWG, appendix A.8, following GLP. The log POW was found to be 4.0 (POW = 9.96E+03).
Reference
Description of key information
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4
- at the temperature of:
- 25 °C
Additional information
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