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Description of key information

The substance 2-phenylpropan-1-ol was tested for acute oral toxicity to rats and an LD50 of 2.3 g/kg bw was found. When tested for acute dermal toxicity to rabbits, and LD50 of >5 g/kg bw was found.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September 1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Qualifier:
no guideline followed
Principles of method if other than guideline:
The studies were performed in 1974, prior to availability of OECD guidelines and EU-testing methods, but however do follow scientific principles.
Oral toxicity was tested at six different dose levels with 10 rats each, whereas deraml toxicity was only tested at one dose level (5 g/kg bw) as this value already was lower than the LD50 (1 out of 5 animals died). Symptom observed were recorded and reported.
GLP compliance:
no
Remarks:
pre-dates GLP
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
male/female
Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
Six doses (5, 3, 2.5, 2, 1 and 0.5 g/kg bw) were applied to 10 animals per dose group.
No. of animals per sex per dose:
10 animals per dose group (5m & 5f)
Control animals:
no
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 300 mg/kg bw
Based on:
test mat.
95% CL:
>= 1 893 - <= 2 707
Mortality:
At 5 g/kg bw all animals died (8 on day 1, 1 on day 2 and 1 on day 4)
At 3 g/kg bw eight animals died on day 1, but none thereafter
At 2.5 g/kg bw five animals died on day 1, but none thereafter
At 2 g/kg bw 3 animals died on day 1 and none thereafter
At 1 g/kg one animal died on day 1 and none thereafter
At 0.5 g/kg bw none of the animals died
Clinical signs:
other: Ataxia, depression, loss of righting reflex, increased respiration, tremors and twitches were observed symptoms.
Gross pathology:
no data
Interpretation of results:
Category 5 based on GHS criteria
Remarks:
not applicable to CLP
Conclusions:
The LD50 determined was 2.3 ±0.407 g/kg bw.
Executive summary:

The substance was assessed for acute oral toxicity to rats, by applying six different doeses (0.5, 1, 2, 2.5, 3 and 5 g/kg bw) to groups of 10 rats each (males and females). Mortality was observed at all dose groups except of 0.5 g/kg bw. The LD50 determined was 2.3 ±0.407 g/kg bw. Symptoms observed were ataxia, depression, loss of righting reflex, increased respiration, tremors and twitches.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 300 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September 1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Qualifier:
no guideline followed
Principles of method if other than guideline:
The studies were performed in 1974, prior to availability of OECD guidelines and EU-testing methods, but however do follow scientific principles.
Oral toxicity was tested at six different dose levels with 10 rats each, whereas deraml toxicity was only tested at one dose level (5 g/kg bw) as this value already was lower than the LD50 (1 out of 5 animals died). Symptoms observed were recorded and reported.
GLP compliance:
no
Remarks:
pre-dates GLP guidelines
Test type:
standard acute method
Limit test:
no
Species:
rabbit
Strain:
not specified
Sex:
male/female
Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
5 g/kg bw was applied neat to rabbit skin
Duration of exposure:
24 hours exposure
Doses:
5 g/kg bw
No. of animals per sex per dose:
5 animals (males and females)
Control animals:
no
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
One out of 5 animals died on day 1; thereafter during 14 days observation period no further mortality was observed
Clinical signs:
other: No skin irritation was seen.
Gross pathology:
not reported
Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 (dermal, rabbit) was found being > 5000 mg/kg bw.
Executive summary:

Five rabbits (male and female) were exposed to 5 g/kg bw during 24 hours exposure period and mortality was observed for 14 days. One animal died on day 1, but thereafter no further mortality was observed. Therefore, the LD50 was determined at >5000 mg/kg bw and no further dose groups were exposed. No skin irritation was observed during the study.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

At 5000 mg/kg bw dermal exposure to rabbits only one animal out of five died; thus, the LD50 was determined as >5000 mg/kg bw.

Justification for classification or non-classification