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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September 1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The studies were performed in 1974, prior to availability of OECD guidelines and EU-testing methods, but however do follow scientific principles.
Oral toxicity was tested at six different dose levels with 10 rats each, whereas deraml toxicity was only tested at one dose level (5 g/kg bw) as this value already was lower than the LD50 (1 out of 5 animals died). Symptom observed were recorded and reported.
GLP compliance:
no
Remarks:
pre-dates GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylpropan-1-ol
EC Number:
214-379-7
EC Name:
2-phenylpropan-1-ol
Cas Number:
1123-85-9
Molecular formula:
C9H12O
IUPAC Name:
2-phenylpropan-1-ol
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
Six doses (5, 3, 2.5, 2, 1 and 0.5 g/kg bw) were applied to 10 animals per dose group.
No. of animals per sex per dose:
10 animals per dose group (5m & 5f)
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 300 mg/kg bw
Based on:
test mat.
95% CL:
>= 1 893 - <= 2 707
Mortality:
At 5 g/kg bw all animals died (8 on day 1, 1 on day 2 and 1 on day 4)
At 3 g/kg bw eight animals died on day 1, but none thereafter
At 2.5 g/kg bw five animals died on day 1, but none thereafter
At 2 g/kg bw 3 animals died on day 1 and none thereafter
At 1 g/kg one animal died on day 1 and none thereafter
At 0.5 g/kg bw none of the animals died
Clinical signs:
other: Ataxia, depression, loss of righting reflex, increased respiration, tremors and twitches were observed symptoms.
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
not applicable to CLP
Conclusions:
The LD50 determined was 2.3 ±0.407 g/kg bw.
Executive summary:

The substance was assessed for acute oral toxicity to rats, by applying six different doeses (0.5, 1, 2, 2.5, 3 and 5 g/kg bw) to groups of 10 rats each (males and females). Mortality was observed at all dose groups except of 0.5 g/kg bw. The LD50 determined was 2.3 ±0.407 g/kg bw. Symptoms observed were ataxia, depression, loss of righting reflex, increased respiration, tremors and twitches.