Registration Dossier
Registration Dossier
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EC number: 214-379-7 | CAS number: 1123-85-9
Endpoint summary
Administrative data
Description of key information
A subchronic oral toxicity study, dosed via feed at concentrations of 10, 40 and 160 mg/kg bw/day, has revealed few effects that can be definitely attributed to treatment. The liver- and kidney-weight increases are considered to be treatment-related, although it is uncertain whether these were toxic or adaptive effects. Hence, clear adverse effects were not identified in this study and the authors, on this basis, have set the no-effect level (NOEL) for this study to 10 mg/kg/day.
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subchronic
- Experimental exposure time per week (hours/week):
- 13
- Species:
- rat
- Organ:
- kidney
- liver
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In lack of clear adverse effects ina subchronic toxicity study via feed, a classification according to CLP (Regulation EC No 127272008) for STOT repeat exposure is not required.
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