Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-351-5 | CAS number: 139-07-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Based on the available weight of evidence information from OECD 30B and OECD 301D studies with the test and/or the read across substances showing degradation percentages ranging from 23 to 100% for the test substance and 88.9% for the read across substance at a range of concentrations, suggests that the test substance, C12 ADBAC can be overall considered to be readily biodegradable.
Study 1:A study was conducted to determine the ready biodegradability of the test substance, C12 ADBAC (purity not specified), using closed bottle test, according to the OECD Guideline 301D. The inoculum used was one drop/L of filtered effluent from sewage works treating predominantly domestic sewage. The test was conducted in two different laboratories using 2, 3.2 and 5 mg/L test concentrations at 20 +/- 1 deg C, followed by BOD determinations after 5, 15 and 28 days. The three test concentrations resulted in 43, 23 and 36% degradation after 28 days. The lowest (2 mg/L) and highest concentrations (5 mg/L) revealed long delay with partial degradation, while the mid concentration (3.2), showed little or no biodegradation. The lag phase was attributed to the toxicity of the test substance to the inoculum. Based on the growth inhibition test conducted for test substance, the EC50 value was determined to be 3.2 -7.5 mg/L. Therefore, the test concentration below the EC50 value i.e., 2 mg/L results in the highest degradation potential. No further details about biodegradation were available. Under the study conditions, the test substance was considered to be not readily biodegradable and this is attributed to the toxicity of the test substance to the inoculum instead of inertness (ECETOC, 1986).
Study 2:A study was conducted to determine the ready biodegradability of the test substance, C12 ADBAC (purity not specified), using Sturm test, according to the OECD Guideline 301B. The inoculum used was collected from a local sewage works which treated predominantly domestic effluents. The inoculum at a concentration of 15 mg/L suspended solids (SS) was pre-aerated for eight days at 23 deg C in the mineral solution before addition of the test substance. The test was conducted at two test concentrations: 6.8 and 13.5 mg/L at 23 deg C, followed by CO2 determinations after 3, 5, 7, 14 and 21 days. The two test concentrations resulted in 100 and 92% degradation after 21 days. Based on the growth inhibition test conducted for test substance, the EC50 value was determined to be 10 - 24 mg/L. Therefore, the test concentration below the EC50 value i.e., 6.8 mg/L results in the highest degradation potential. No further details about biodegradation were available. Under the study conditions, the test substance was considered to be readily biodegradable (ECETOC, 1986).
Study 3: A study was conducted to determine the biodegradation of the read across substance, C12-16 ADBAC (purity not specified), in water according to OECD Guideline 301B (CO2 evolution test). Flasks containing inoculum from a household water-treating plant dosed with the equivalent of 5 mg C/L test or 20 mg C/L reference substances were maintained for 28 d. Testing at low concentrations, was required due to the toxicity of the read across substance towards the inoculum at higher concentrations. Biodegradability was calculated from the released CO2 over time in the test and reference flasks compared to the blank control (a flask prepared without test or reference substance). CO2 production in the blank (inoculum control) was 39.2 mg. Biodegradability in the reference flask was determined to be 88.9% after 28 d. Under the test conditions, the biodegradation of the read across substance in water was determined to be 95.5% after 28 d (CO2 evolution). The read across substance was considered to be readily biodegradable (van Dievoet, 2005). Based on the results of read across substance study, similar degradation potential can be expected for the test substance.
The available information on the test and read across substances indicates that the slow or lag in the degradation potential of the substances at higher concentrations is not due to inertness of the substance but due to toxicity to the inoculum. It is generally recommended that the concentration of the substance in the biodegradation test should not exceed 1/10th of the EC50 determined in the toxicity tests. However, this was not the case in the available biodegradation tests with the test substance, as the EC50 value for toxicity to micro-organisms ranges from 3.2-40 mg/L (ECETOC, 1986). In light of these facts and based on the available weight of evidence information from studies with the test and/or the read across substances, suggests that the test substance, C12 ADBAC can be overall considered to be readily biodegradable.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
