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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1958
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study not under GLP.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1959

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Predates establishment of OECD guideline and GLP. Standard acute oral gavage dosing of rats with 21 day observation period.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl O-acetylcitrate
EC Number:
201-067-0
EC Name:
Tributyl O-acetylcitrate
Cas Number:
77-90-7
Molecular formula:
C20H34O8
IUPAC Name:
tributyl 2-acetoxypropane-1,2,3-tricarboxylate
Details on test material:
Citroflex A-4, acetyl tributyl citrate (ATBC), 99.9 % purity

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Administered via oral gavage at 10-30 ml/kg bw.
Doses:
10 - 30 g/kg bw, equivalent to 10,000 to 30,000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Observation for 21 days after dosing

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
10 000 mg/kg bw
Based on:
test mat.
Remarks on result:
not determinable due to absence of adverse toxic effects
Remarks:
LD50 may be as high as 30000 mg/kg bw
Mortality:
No deaths
Clinical signs:
other: Leakage of the material from the rectum. Animals appeared somewhat sluggish but recovered promptly, showing no signs suggesting systemic toxicity in the ensuing 3 weeks.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In a study of acute oral toxicity in 5 Wistar rats, the test material was given via gavage at doses between approximately 10,000 and 30,000 mg/kg bw. No lethality or toxicity was observed. The LD50 is > 10,000 mg/kg bw.