Registration Dossier

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 3',5-diallyl[biphenyl]-2,4'-diol and 5,5'-diallyl[biphenyl]-2,2'-diol
Cas Number:
947686-05-7
Molecular formula:
C18H18O2
IUPAC Name:
Reaction mass of 3',5-diallyl[biphenyl]-2,4'-diol and 5,5'-diallyl[biphenyl]-2,2'-diol
Test material form:
solid

Results and discussion

In vitro

Resultsopen allclose all
Irritation / corrosion parameter:
% tissue viability
Value:
>= 11.9
Vehicle controls validity:
valid
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Value:
>= 113.6
Vehicle controls validity:
valid
Negative controls validity:
valid
Positive controls validity:
valid

Applicant's summary and conclusion

Conclusions:
Magnolia Officinalis Bark Extract is considered non-corrosive to skin in the Reconstructed Human Epidermis (RHE) Test Method.