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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 3',5-diallyl[biphenyl]-2,4'-diol and 5,5'-diallyl[biphenyl]-2,2'-diol
Cas Number:
947686-05-7
Molecular formula:
C18H18O2
IUPAC Name:
Reaction mass of 3',5-diallyl[biphenyl]-2,4'-diol and 5,5'-diallyl[biphenyl]-2,2'-diol
Test material form:
solid

Results and discussion

In vitro

Results
Irritation parameter:
in vitro irritation score
Value:
ca. ca. 33.8
Vehicle controls validity:
valid
Negative controls validity:
valid
Positive controls validity:
valid
Remarks on result:
positive indication of irritation

Applicant's summary and conclusion

Interpretation of results:
Category 2A (irritating to eyes) based on GHS criteria
Conclusions:
According to the OECD Guideline 492, the EpiOcularTM Eye Irritation Test does not allow discrimination between eye irritation/reversible effects on the eye (Category 2) and serious eye damage/irreversible effects on the eye (Category 1). For these purposes, further testing with other suitable test methods is required.
Under the conditions of the test, Magnolia Officinalis Bark Extract is considered ei-ther eye irritant or inducing serious eye damage in the EpiOcularTM Eye Irritation Test.