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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10/ 2000 - 02/ 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study performed according to GLP and OECD guidelines
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
Principles of method if other than guideline:
-
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methyloxazole-5-carbonitrile
EC Number:
213-709-7
EC Name:
4-methyloxazole-5-carbonitrile
Cas Number:
1003-52-7
Molecular formula:
C5H4N2O
IUPAC Name:
4-methyl-1,3-oxazole-5-carbonitrile

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
2000, 930, 430, 200 mg/kg BW
No. of animals per sex per dose:
5 per sex per dose
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
735 mg/kg bw
95% CL:
>= 452 - <= 1 199
Sex:
female
Dose descriptor:
LD50
Effect level:
632 mL/kg bw
95% CL:
>= 267 - <= 1 500

Any other information on results incl. tables

no additional remarks

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of Cyanomethyloxazol was determined to 735.87 mg/kg for male rats and to 632.46 mg/kg for female rats according to the Moving Averages Computation.
Executive summary:

The test substance was administered orally in a single dose to four groups of Sprague Dawley rats: Group I (l0 rats, 5 males and 5 females) 2000 mg/kg applied; Group II (l0 rats, 5 males and 5 females) 930 mg/kg applied Group III (10 rats, 5 males and 5 females) 430 mg/kg applied Group IV (10 rats, 5 males and 5 females) 200 mg/kg applied. Mortality attributed to the exposure to Cyanomethyloxazol could be observed in 10 rats dosed with 2000 mg/kg, in 8 rats dosed with 930 mg/kg, in 1 rat dosed with 430 mg/kg and in 0 rats dosed with 200 mg/kg. The post-mortem findings did not show any macroscopic organ changes. The LD50 value of Cyanomethyloxazol was determined to 735.87 mg/kg for male rats and to 632.46 mg/kg for female rats according to the Moving Averages Computation.