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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10/ 2000 - 02/ 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study performed according to GLP and OECD guidelines
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
Principles of method if other than guideline:
-
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methyloxazole-5-carbonitrile
EC Number:
213-709-7
EC Name:
4-methyloxazole-5-carbonitrile
Cas Number:
1003-52-7
Molecular formula:
C5H4N2O
IUPAC Name:
4-methyl-1,3-oxazole-5-carbonitrile

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
2000, 930, 430, 200 mg/kg BW
No. of animals per sex per dose:
5 per sex per dose
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
735 mg/kg bw
95% CL:
>= 452 - <= 1 199
Sex:
female
Dose descriptor:
LD50
Effect level:
632 mL/kg bw
95% CL:
>= 267 - <= 1 500

Any other information on results incl. tables

no additional remarks

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of Cyanomethyloxazol was determined to 735.87 mg/kg for male rats and to 632.46 mg/kg for female rats according to the Moving Averages Computation.
Executive summary:

The test substance was administered orally in a single dose to four groups of Sprague Dawley rats: Group I (l0 rats, 5 males and 5 females) 2000 mg/kg applied; Group II (l0 rats, 5 males and 5 females) 930 mg/kg applied Group III (10 rats, 5 males and 5 females) 430 mg/kg applied Group IV (10 rats, 5 males and 5 females) 200 mg/kg applied. Mortality attributed to the exposure to Cyanomethyloxazol could be observed in 10 rats dosed with 2000 mg/kg, in 8 rats dosed with 930 mg/kg, in 1 rat dosed with 430 mg/kg and in 0 rats dosed with 200 mg/kg. The post-mortem findings did not show any macroscopic organ changes. The LD50 value of Cyanomethyloxazol was determined to 735.87 mg/kg for male rats and to 632.46 mg/kg for female rats according to the Moving Averages Computation.