Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with column 2 of REACH Annex VIII, this study does not need to be conducted if the substance is highly insoluble in water.
Key value for chemical safety assessment
Additional information
Testing was not carried out using Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008.
This was because the water solubility was low, determined to be≤1.4 x 10-4 g/L. The hydrolysis test would have had to be performed at no more than half this value, as stipulated in the guidelines, and would have been below the sensitivity of relevant analytical techniques to quantify the concentration of test item as it decreased due to hydrolysis. Therefore, extraction procedures were attempted to concentrate the test item in solution, namely solid phase extraction cartridges and solvent/solvent extraction using dichloromethane.
However, even though recovery was relatively successful at higher levels (0.5 mg/L gave approximately 75 % recovery) it was noticed that as the sample concentration became lower the recovery efficiency also reduced. At 0.1 mg/L a recovery of approximately 55 % was achieved but at 0.01 mg/L this had dropped to approximately 25 %. Therefore, as the test item concentration reduced due to hydrolysis, the extracted sample concentration would reduce even further due to the decreasing efficiency of the extraction procedure. This would then not produce a straight line hydrolysis plot with time.
Although the test was not performed due to the above reasons, it was known that the test item would hydrolyse and seen to degrade in solution during the study. The functional group present within the test item that is well known to hydrolyse is an ester. Being part of a 5 membered ring may put strain on the structure and increase the rate of hydrolysis which would alleviate the strain by opening the ring. Esters are well known to hydrolyse at all pHs, but significantly in strong basic conditions and to a lesser degree in strong acidic conditions. The other functional groups within the test item structure, an hydroxyl, aryl and ether, would not be expected to hydrolyse in environmental conditions of pH and temperature.
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