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EC number: - | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Under the conditions of the test, fish exposed to the hydrolysis product of the test material in a 100 % v/v saturated solution displayed no mortality or signs of sub-lethal effects. 96 hour LC50 > 100 % (saturated solution), NOEC = 100 % (saturated solution), OECD 203, EU Method C.1, Parr 2013.
Key value for chemical safety assessment
Additional information
The acute toxicity of the test material to fish was determined using rainbow Trout (Oncorhynchus mykiss) in a study performed under GLP conditions and in accordance with the standardised guidelines OECD 203 and EU Method C.1.
Since the test material is known to rapidly hydrolyse in water (half-life approximately 1-Hour in deionized reverse osmosis water) fish were exposed to the hydrolysis product in a limit test at 100 % v/v saturated solution in accordance with the OECD guidance 23 (Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures). Analysis of the test preparations was performed using HPLC-MS at 0, 24, 72 and 96 hour. Measured concentrations were less than the limit of quantitation (0.81 mg/L). Given that measured concentrations could not be obtained in this study the results were based on nominal concentrations.
Seven fish were exposed the hydrolysis solution for 96 hours under semi-static conditions and observed for any mortalities and sub-lethal effects.
Under the conditions of the test, fish exposed to the hydrolysis product of the test material in a 100 % v/v saturated solution displayed no mortality or signs of sub-lethal effects. Accordingly the LC50 was determined to be > 100 % v/v saturated solution, and the NOEC 100 % v/v saturated solution. This study showed that there were no toxic effects at the limit of water solubility.
This key study was performed in line with GLP and accepted standardised guidelines with a high standard of reporting. The study was assigned a reliability score of 1 in accordance with the criteria outlined by Klimisch (1997) and considered suitable for assessment as an accurate reflection of the test material.
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