Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 21, 2015 to June 05, 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Name (as stated in the report): GR-88-0778
Lot No: Batch 6
Aspect: Colourless liquid
Expiration date: March 29, 2017
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.7
Temp.:
35 °C
pH:
7
Conclusions:
In the conditions of the test, the chromatograms of GR-88-0778 show one peak at an average retention time of 7.628 minutes, corresponding to a partition coefficient (log value) of 3.7.Therefore:Partition coefficient n-octanol/water of GR-88-0778: log Pow = 3.7N.B.: The determination was performed at 35°C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Executive summary:

The Partition Coefficient n-octanol/water of GR-88-0778 was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

 The result is:

Partition coefficient n-octanol/water of GR-88-0778:     log Pow= 3.7

Description of key information

The Partition Coefficient n-octanol/water of GR-88-0778 was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.7
at the temperature of:
35 °C

Additional information