2,3-bis((2-mercaptoethyl)thio)-1-propanethiol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1998 - 1990

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Report date:

1990

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

4-mercaptomethy1-3,6-dithia-1,8-octanedithiol

IUPAC Name:

4-mercaptomethy1-3,6-dithia-1,8-octanedithiol

Test material form:

solid - liquid: suspension

Details on test material:

- Lot/batch No.: 111

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Doses:

250, 500, 1000, 2500, 4000 and 5000 mg/kg

No. of animals per sex per dose:

Range-finding Study: 1 animal/sex/dose.
LD50-Determination: 5 animals/sex/dose.

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

3 428 mg/kg bw

Based on:

test mat.

95% CL:

2 354 - 4 994

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

3 643 mg/kg bw

Based on:

test mat.

95% CL:

1 779 - 7 458

Effect levels 3

Sex:

male/female

Dose descriptor:

LD50

Effect level:

3 577 mg/kg bw

Based on:

test mat.

95% CL:

2 651 - 4 826

Mortality:

Male: 1200 mg/kg bw/d; Number of animals: 5; Number of deaths: 0
Male: 2500 mg/kg bw/d; Number of animals: 5; Number of deaths: 2
Male: 5000 mg/kg bw/d; Number of animals: 5; Number of deaths: 3
Female: 1200 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 4

Clinical signs:

other: Signs seen on the day of dosing in most groups included oral discharge, urinary and fecal staining, soft stool and hypoactivity. Additional signs seen on the day after dosing included nasal discharge and abdominal griping in the 5000 mg/kg dose group only

Gross pathology:

Postmortem examinations of animals which were found dead revealed a variety of changes, primarily in the lungs and gastrointestinal tract. Some animals which were found dead exhibited changes in the stomach and intestine which were suggestive of an irritant and/or corrosive effect (discoloration of walls, the presence of red, tan or black material). Other changes in animals found dead appeared to represent autolytic changes or were the result of ante-mortem stress (testes in the body cavity). Changes in animals killed after 14 days were similar to those seen in control animals in this laboratory killed by carbon dioxide inhalation or were considered to represent normal physiological variation.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The oral toxicity of DMPT in rats is low (LD50 above 3,000 mg/kg/d). The anticipated mean oral LD50 of 3577 mg/kg/d of DMPT allows classification in OECD GHS Toxicity Category IV.