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EC number: 411-290-7 | CAS number: 131538-00-6 MR-7 B; MR-8 B2; MR-S2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The substance needs to be classified as a skin sensitizer based on human work experience (laboratory and production plant).
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. EPA Pesticide Assessment Guidelines Subdivision F, Part 81-6
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- The study was conducted in 1993 and can be used as a surrogate for a LLNA.
- Species:
- guinea pig
- Strain:
- other: Hartley Dunkin Pirbright White
- Sex:
- not specified
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: Intradermal: paraffin oil. Epicutaneous: petrolatum.
- Concentration / amount:
- Concentration of test material and vehicle used at induction:
a) Primary induction (intradermal): 0.2% in paraffin oil
b) Secondary induction (topical): 1% in petrolatum (gauze)
Concentration of test material and vehicle used for each challenge:
0.005% in petrolatum (gauze). - Route:
- other: topical
- Vehicle:
- other: Intradermal: paraffin oil. Epicutaneous: petrolatum.
- Concentration / amount:
- Concentration of test material and vehicle used at induction:
a) Primary induction (intradermal): 0.2% in paraffin oil
b) Secondary induction (topical): 1% in petrolatum (gauze)
Concentration of test material and vehicle used for each challenge:
0.005% in petrolatum (gauze). - No. of animals per dose:
- Number of animals in test group: 22
Number of animals in negative control group: 22 - Positive control substance(s):
- no
- Reading:
- rechallenge
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.005%
- No. with + reactions:
- 0
- Total no. in group:
- 22
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.005%
- No. with + reactions:
- 0
- Total no. in group:
- 22
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- positive control
- Dose level:
- 0.025 % dilution in vaseline
- No. with + reactions:
- 22
- Total no. in group:
- 22
- Remarks on result:
- positive indication of skin sensitisation
- Reading:
- rechallenge
- Hours after challenge:
- 48
- Group:
- positive control
- Dose level:
- 0.025 % dilution in vaseline
- No. with + reactions:
- 22
- Total no. in group:
- 22
- Remarks on result:
- positive indication of skin sensitisation
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 22
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- rechallenge
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 22
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- It was conluded that GST does not cause any primaty sensittization in guinea-pigs using the Magnusson-Kligman method.
However, the substance needs to be classified as potential skin sensitizer based on human experience in one production plant According to Annex VI of CLP (1272/2008/EC)
Reference
Signs of irritation during induction:
During the first induction, the Draize score was lower for the groups that were injected with the vehicle without test substance than in the group injected with the test substance.
Evidence of sensitisation of each challenge concentration:
While the sensibilized animals did not exhibit a reaction during the challenge, a slight reaction was observed in the animals in the control group after 48 hours.
The reaction to the first challenge was read at 48 hrs only, while the reaction to the rechallenge was read at 24 hrs only. No additional information is available.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The skin sensitising potential of 2,3 -bis((2 -mercaptoethyl)thio)-1-propanethiol was evaluated in a study performed under GLP and according to U.S. EPA Pesticide Assessment Guidelines, Subdivision F, Part 81 -6, similar to the Guinea Pig Maximisation Test of Magnusson and Kligman (Mitsui 1993, SNIF#001-4.1.70 -01). No skin effects were observed in the animals challenged with the test substance. Therefore, 2,3-bis((2 -mercaptoethyl)thio)-1-propanethiol is not considered to be sensitising under the test conditions.
However, observations with the test substance at the production plant reported by the manufacturer lead us to conclude that there is evidence that the substance could be a skin sensitiser in humans.
Migrated from Short description of key information:
There is sufficient information from experience in humans that DMPT could be a skin sensitiser. This is in contrast to the guinea pig maximisation test conducted in 1993.
Justification for selection of skin sensitisation endpoint:
Key study
Justification for classification or non-classification
According to Annex I of DSD (67/548/EC), the available data on 2,3-bis((mercaptoethyl)thio)-1-propanethiol are sufficient for classification.
According toAnnex VI of CLP (1272/2008/EC), the available data on 2,3-bis((mercaptoethyl)thio)-1-propanethiol are sufficient for classification.
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