Octadecan-1-ol, ethoxylated, phosphates

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1 October 2018 to 14 March 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to other study

Remarks:

Additional water solubility information is available in the Algal Growth Inhibition Test.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

Purity: 100% (UVCB)
Appearance/Physical state: Solid, white pastille
Storage: Room temperature in the dark

Key result

Water solubility:

>= 0.015 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

ca. 4.3 - ca. 4.4

As the test item is a UVCB, the shake flask method was performed.

The three definitive test samples gave widely varied results. There was also no trend across the three samples with respect to test item contact time with the purified water. Therefore, the highest concentration result has been used as a limit value for the water solubility endpoint.

As the test item was confirmed to be surface-active in the surface tension test and all three cleaned-up solutions indicated a distinct Tyndall beam, it is possible that the test results were due to emulsification as opposed to actual solubility.

As such, it was considered that further testing was unnecessary in this instance.

Conclusions:

In a study conducted according to OECD 105, using the shake flask method, the water solubility has been determined to be less than or equal to
1.45 E-2 g/L of solution at 20.0 +/- 0.5 deg.C.

Executive summary:

The water solubility of the test item was detemined to be less than or equal to 1.45 E-2 g/L of solution at 20.0 +/- 0.5 deg. C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008, and OECD Guidelines for Testing of Chemicals No. 105, 27 July 1995.

In an algal growth inhibition test, the substance concentration in the test samples collected at 0, 24, 48 and 72 hours was determined by high performance liquid chromatography with mass spectrometry (HPLC-MS) using an external standard. Quantitation was based on a single peak attributed to the major component of the test item. Analysis of the test preparations at 0 hours showed that measured test concentrations ranged from 0.0022 to 0.67 mg/L. At 72 hours, measured concentrations ranged from less than the Limit of Quantification (LOQ, 0.000516 mg/L) to 0.0095 mg/L.

Description of key information

In a study conducted according to OECD 105, using the shake flask method, the water solubility has been determined to be less than or equal to 1.45 E-2 g/L of solution at 20.0 +/- 0.5 deg.C.